{"created":"2021-03-01T06:12:13.797863+00:00","id":8224,"links":{},"metadata":{"_buckets":{"deposit":"a1b92526-873f-43e3-ae2a-a40b26b1dbb2"},"_deposit":{"id":"8224","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8224"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00008224","sets":["453:456","471:537:538:884"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Biologic Therapy for Psoriasis"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"469","bibliographicPageStart":"464","bibliographicVolumeNumber":"131","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"生物学的製剤の登場は，既存の治療で難渋していた重症乾癬患者における皮疹のコントロールや乾癬性関節炎患者における関節破壊の進展抑制を可能にした．現在わが国で乾癬に対して使用可能な生物学的製剤は6剤あり，標的とする分子，抗体の種類，作用機序，投与経路や投与間隔など，それぞれに特徴がある．いずれの製剤も有効性は高いが，反面，副作用や高額な費用などの問題があり，適応症例を慎重に選択した上で，十分な説明と同意に基づいて投与を決定する必要がある．現在当科では，既存治療に抵抗性の症例，重症例や強い関節症状を有する症例を対象に，インフリキシマブ，アダリムマブ，ウステキヌマブ，セクキヌマブ，イキセキズマブの5剤を病型，年齢，合併症，利便性などを考慮して選択している．これまで大きな有害事象はなく，多くの症例において期待した効果を得られている．今後もさらに新規の生物学的製剤の開発が進行中であり，各製剤の特徴を生かした有効な使用方法の確立のためのデータの蓄積と解析が待たれる．","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"57744","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Fujimoto, Atsushi"}]},{"nameIdentifiers":[{"nameIdentifier":"57745","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Abe, Riichiro"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤本, 篤"}],"nameIdentifiers":[{"nameIdentifier":"57742","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"阿部, 理一郎"}],"nameIdentifiers":[{"nameIdentifier":"57743","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"131(8)_464-469.pdf","filesize":[{"value":"2.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"131(8)_464-469.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/8224/files/131(8)_464-469.pdf"},"version_id":"7b2d72ef-3418-493b-96fd-a942f1cc5c3c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"乾癬","subitem_subject_scheme":"Other"},{"subitem_subject":"生物学的製剤","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"5 皮膚科領域 乾癬における生物学的製剤治療 （シンポジウム 各科領域における生物学的製剤の現況と展望, 第720回新潟医学会）","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"5 皮膚科領域 乾癬における生物学的製剤治療 （シンポジウム 各科領域における生物学的製剤の現況と展望, 第720回新潟医学会）"},{"subitem_title":"5 皮膚科領域 乾癬における生物学的製剤治療 （シンポジウム 各科領域における生物学的製剤の現況と展望, 第720回新潟医学会）","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","884"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-28"},"publish_date":"2018-02-28","publish_status":"0","recid":"8224","relation_version_is_last":true,"title":["5 皮膚科領域 乾癬における生物学的製剤治療 （シンポジウム 各科領域における生物学的製剤の現況と展望, 第720回新潟医学会）"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:42:36.032046+00:00"}