{"created":"2021-03-01T06:12:10.431584+00:00","id":8170,"links":{},"metadata":{"_buckets":{"deposit":"f26dc5eb-e872-4ec7-a2c9-4928310e713c"},"_deposit":{"id":"8170","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8170"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00008170","sets":["453:456","471:537:538:881"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Precision Medicine in patients with Colorectal Cancer"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"625","bibliographicPageStart":"622","bibliographicVolumeNumber":"131","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"次世代シークエンサーを用いた包括的な癌関連遺伝子変異解析により，大腸癌を含む固形癌患者に対するPrecision Medicineが可能となる．次世代シークエンサーによる遺伝子変異解析においては，ホルマリン固定パラフィン包埋サンプルの精度管理が重要である．ホルマリン固定パラフィン包埋サンプル作製において重要な点は， 10％中性緩衝ホルマリン固定液を使用すること，固定時間は48時間以内とすることである．また，ホルマリン固定パラフィン包埋サンプルの経年劣化を考慮して7年以内に解析を行うことである．これまで大腸癌を含む固形癌患者に対する薬物療法は，臓器ごとに縦割りに行われてきた．しかし，現在ではドライバー遺伝子変異により，対応する薬剤が臓器横断的に使用されるようになってきている．例えば，HER2陽性の乳癌および胃癌に対して,抗HER2療法が有効である．近年では，HER2陽性の大腸癌に対しても，抗HER2療法の有効性が示されている． このように，今後はHER2などの分子標的薬と関連するバイオマーカーを基盤とした臓器横断的分類が重要となると考えられる．","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"57485","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Shimada, Yoshifumi"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"島田, 能史"}],"nameIdentifiers":[{"nameIdentifier":"57484","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"131(11)_622-625.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"131(11)_622-625.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/8170/files/131(11)_622-625.pdf"},"version_id":"0149f406-3899-4454-821c-d29bf33e293a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"大腸癌","subitem_subject_scheme":"Other"},{"subitem_subject":"Precision Medicine","subitem_subject_scheme":"Other"},{"subitem_subject":"次世代シークエンサー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"2 大腸癌のPrecisionMedicineに向けて（シンポジウム Precision Cancer Medicine, 第722回新潟医学会）","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"2 大腸癌のPrecisionMedicineに向けて（シンポジウム Precision Cancer Medicine, 第722回新潟医学会）"},{"subitem_title":"2 大腸癌のPrecisionMedicineに向けて（シンポジウム Precision Cancer Medicine, 第722回新潟医学会）","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","881"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-07"},"publish_date":"2018-05-07","publish_status":"0","recid":"8170","relation_version_is_last":true,"title":["2 大腸癌のPrecisionMedicineに向けて（シンポジウム Precision Cancer Medicine, 第722回新潟医学会）"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:42:34.549671+00:00"}