{"created":"2021-03-01T06:12:07.648659+00:00","id":8125,"links":{},"metadata":{"_buckets":{"deposit":"248c5225-e6ae-41b5-a59b-06e7887c9a08"},"_deposit":{"id":"8125","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8125"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00008125"},"item_7_alternative_title_1":{"attribute_name":"\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_alternative_title":"Association of Heterozygous Mutations in high temperature requirement A serine peptidase 1 and Cerebral Small Vessel Disease"}]},"item_7_biblio_info_6":{"attribute_name":"\u66f8\u8a8c\u60c5\u5831","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"114","bibliographicPageStart":"105","bibliographicVolumeNumber":"132","bibliographic_titles":[{"bibliographic_title":"\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"},{"bibliographic_title":"\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"\u6284\u9332","attribute_value_mlt":[{"subitem_description":"high-temperature requirement A serine peptidase 1(HTRA1)\u5909\u7570\u306e\u30db\u30e2\u3082\u3057\u304f\u306f\u8907\u5408\u3078\u30c6\u30ed\u63a5\u5408\u4f53\u306f\u907a\u4f1d\u6027\u8133\u5c0f\u8840\u7ba1\u75c5\u3092\u304a\u3053\u3059\uff0e\u4e00\u65b9\uff0c\u8fd1\u5e74\uff0c\u8133\u5c0f\u8840\u7ba1\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066HTRA1\u5909\u7570\u306e\u30d8\u30c6\u30ed\u63a5\u5408\u4f53\u304c\u8907\u6570\u4f8b\u5831\u544a\u3055\u308c\u305f. HTRA1\u306f\u30bb\u30ea\u30f3\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3067\u3042\u308a, 3\u91cf\u4f53\u3068\u306a\u308b\u4e8b\u3067\u305d\u306e\u6d3b\u6027\u3092\u8abf\u7bc0\u3057\u3066\u3044\u308b\uff0e\u7b46\u8005\u3089\u306f,HTRA1\u5909\u7570\u3078\u30c6\u30ed\u63a5\u5408\u4f53\u3067\u8a8d\u3081\u3089\u308c\u305fHTRA1\u5909\u7570\u306e\u75c5\u614b\u6a5f\u5e8f\u3068\u3057\u3066\uff0c\u5909\u7570\u578bHTRA1\u304c\u512a\u6027\u963b\u5bb3\u52b9\u679c(dominant negative effects: DN)\u3092\u793a\u3059\u3053\u3068\u3092\u63d0\u5531\u3057\u3066\u304d\u305f\uff0e\u672c\u7814\u7a76\u3067\u306f,\u65e2\u5831\u306e\u5909\u7570\u578bHTRA1\u306eDN\u306e\u6709\u7121\u3092\u89e3\u6790\u3057,\u672c\u4eee\u8a2d\u3092\u691c\u8a3c\u3057\u305f\uff0e\u307e\u305a\uff0c\u65e2\u5831\u306e15\u7a2e(S121R,A123S,R133G,R166C,R166L,A173P,A173T,S284G,S284R,P285Q,F286V,G295R,A321T,L364P,D450H)\u306e\u5909\u7570\u578bHTRA1\u306e\u7cbe\u88fd\u86cb\u767d\u3092\u4f5c\u6210\u3057\uff0c\u30ab\u30bc\u30a4\u30f3\u3092\u57fa\u8cea\u3068\u3057\u3066\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u6d3b\u6027\u3092\u6e2c\u5b9a\u3057\u305f\uff0e\u305d\u306e\u7d50\u679c\uff0c11\u7a2e(S121R,R166C,R166L,A173P,A173T,S284R,P285Q,F286V,G295R,A321T,L364P)\u3067\uff0c\u91ce\u751f\u578bHTRA1\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306a\u4f4e\u4e0b\u3092\u8a8d\u3081\u305f\uff0e\u6b21\u306b\uff0c\u91ce\u751f\u578bHTRA1\u3068\u5909\u7570\u578bHTRA1\u3092\u6df7\u5408\u3057\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u6d3b\u6027\u3092\u6e2c\u5b9a\u3057\u305f\u3068\u3053\u308d\uff0c5\u7a2e(R166L,A173P,A173T,S284R,G295R)\u3067DN\u3092\u8a8d\u3081\u305f\uff0e\u3055\u3089\u306b\uff0c\u30b2\u30eb\u6ffe\u904e\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u306b\u30663\u91cf\u4f53\u5f62\u6210\u80fd\u3092\u89e3\u6790\u3057\u305f\u3068\u3053\u308d, DN\u3092\u8a8d\u3081\u308b5\u7a2e\u306e\u5909\u7570\u306e\u3046\u3061\uff0c4\u7a2e(R166L,A173P,A173T,G295R)\u30673\u91cf\u4f53\u306e\u5f62\u6210\u4e0d\u5168\u3092\u8a8d\u3081\u305f\uff0e\u6700\u5f8c\u306bDN\u3092\u8a8d\u3081\u305f\u30d8\u30c6\u30ed\u63a5\u5408\u4f53\u5909\u7570\u4f8b17\u4f8b\u3068DN\u3092\u8a8d\u3081\u306a\u3044\u30d8\u30c6\u30ed\u63a5\u5408\u4f53\u5909\u7570\u4f8b9\u4f8b\u306e\u81e8\u5e8a\u50cf\u3092\u6bd4\u8f03\u3057\u305f\u3068\u3053\u308d, DN\u3092\u8a8d\u3081\u308b\u7fa4\u3067\u75c7\u5019\u6027\u8133\u5c0f\u8840\u7ba1\u75c5\u306e\u983b\u5ea6\u304c\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f(76.5% vs 33.3%, p < 0.046).\u4ee5\u4e0a\u306e\u7d50\u679c\u304b\u3089, DN\u3092\u8a8d\u3081\u308b\u5909\u7570\u578bHTRA1\u306f\uff0c\u30d8\u30c6\u30ed\u63a5\u5408\u4f53\u3067\u75c7\u5019\u6027\u8133\u5c0f\u8840\u7ba1\u75c5\u306e\u767a\u75c7\u306b\u5bc4\u4e0e\u3059\u308b\u3068\u3044\u3046\u4eee\u8aac\u304c\u652f\u6301\u3055\u308c\u305f\uff0e","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"\u8457\u8005\u5225\u540d","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"57194","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Uemura, Masahiro"}]}]},"item_7_publisher_7":{"attribute_name":"\u51fa\u7248\u8005","attribute_value_mlt":[{"subitem_publisher":"\u65b0\u6f5f\u533b\u5b66\u4f1a"}]},"item_7_select_19":{"attribute_name":"\u8457\u8005\u7248\u30d5\u30e9\u30b0","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"\u8457\u8005","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"\u4e0a\u6751, \u660c\u5bdb"}],"nameIdentifiers":[{"nameIdentifier":"57193","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"\u30d5\u30a1\u30a4\u30eb\u60c5\u5831","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"132(3)_105-114.pdf","filesize":[{"value":"5.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"132(3)_105-114.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/8125/files/132(3)_105-114.pdf"},"version_id":"7fc83288-44df-4660-8039-d3083ec4223d"}]},"item_keyword":{"attribute_name":"\u30ad\u30fc\u30ef\u30fc\u30c9","attribute_value_mlt":[{"subitem_subject":"\u8133\u5c0f\u8840\u7ba1\u75c5","subitem_subject_scheme":"Other"},{"subitem_subject":"HTRA1","subitem_subject_scheme":"Other"},{"subitem_subject":"\u30d8\u30c6\u30ed\u63a5\u5408\u4f53\u5909\u7570","subitem_subject_scheme":"Other"},{"subitem_subject":"\u512a\u6027\u963b\u5bb3\u52b9\u679c","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"\u8a00\u8a9e","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"\u8133\u5c0f\u8840\u7ba1\u75c5\u60a3\u8005\u3067\u3078\u30c6\u30ed\u63a5\u5408\u6027\u306b\u8a8d\u3081\u3089\u308c\u305fhigh-temperature requirement A serine peptidase 1(HTRA1)\u5909\u7570\u306e\u75c5\u7684\u610f\u7fa9\u306e\u691c\u8a0e","item_titles":{"attribute_name":"\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_title":"\u8133\u5c0f\u8840\u7ba1\u75c5\u60a3\u8005\u3067\u3078\u30c6\u30ed\u63a5\u5408\u6027\u306b\u8a8d\u3081\u3089\u308c\u305fhigh-temperature requirement A serine peptidase 1(HTRA1)\u5909\u7570\u306e\u75c5\u7684\u610f\u7fa9\u306e\u691c\u8a0e"},{"subitem_title":"\u8133\u5c0f\u8840\u7ba1\u75c5\u60a3\u8005\u3067\u3078\u30c6\u30ed\u63a5\u5408\u6027\u306b\u8a8d\u3081\u3089\u308c\u305fhigh-temperature requirement A serine peptidase 1(HTRA1)\u5909\u7570\u306e\u75c5\u7684\u610f\u7fa9\u306e\u691c\u8a0e","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["453/456","471/537/538/878"],"pubdate":{"attribute_name":"\u516c\u958b\u65e5","attribute_value":"2018-09-19"},"publish_date":"2018-09-19","publish_status":"0","recid":"8125","relation_version_is_last":true,"title":["\u8133\u5c0f\u8840\u7ba1\u75c5\u60a3\u8005\u3067\u3078\u30c6\u30ed\u63a5\u5408\u6027\u306b\u8a8d\u3081\u3089\u308c\u305fhigh-temperature requirement A serine peptidase 1(HTRA1)\u5909\u7570\u306e\u75c5\u7684\u610f\u7fa9\u306e\u691c\u8a0e"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2021-03-01T18:52:06.053580+00:00"}