{"_buckets": {"deposit": "0f2d8a62-e948-4317-8c58-e5eae644cadb"}, "_deposit": {"id": "8123", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "8123"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00008123"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "TGF-beta-Related Proteins in the Inclusions of Adult-onset Neuronal Intranuclear Inclusion Disease"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "92", "bibliographicPageStart": "83", "bibliographicVolumeNumber": "132", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "\u795e\u7d4c\u6838\u5185\u5c01\u5165\u4f53\u75c5\uff08Neuronal intranuclear inclusion disease; NIID\uff09\u306f\u30a8\u30aa\u30b8\u30f3\u597d\u6027\uff0c\u304b\u3064\uff0cp62\u967d\u6027\u306e\u6838\u5185\u5c01\u5165\u4f53\uff08Nuclear inclusion; NI\uff09\u304c\uff0c\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e\u795e\u7d4c\u7d30\u80de\u3084\u30b0\u30ea\u30a2\u7d30\u80de\u306e\u307f\u306a\u3089\u305a\uff0c\u672b\u68a2\u795e\u7d4c\u3084\u4e00\u822c\u81d3\u5668\u306e\u7d30\u80de\u306b\u3082\u5e83\u304f\u51fa\u73fe\u3059\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3067\u3042\u308b\uff0e\u6210\u4eba\u767a\u75c7NIID\u306e\u5927\u591a\u6570\u306f\u767d\u8cea\u8133\u75c7\uff08Leukoencephalopathy; LE\uff09\u3092\u4f34\u3046\u8a8d\u77e5\u75c7\u3092\u5448\u3059\u308b\uff0e\u8fd1\u5e74\uff0c\u8a3a\u65ad\u306b\u76ae\u819a\u751f\u691c\u304c\u6709\u7528\u3067\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u305f\uff0e\u672c\u75be\u60a3\u306e\u75c5\u614b\u6a5f\u5e8f\u306f\u4e0d\u660e\u3067\u3042\u308b\u3082\u306e\u306e\uff0c\u7d44\u7e54\u5b66\u7684\u306b, NI\u306e\u591a\u304f\u306f\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306b\u51fa\u73fe\u3057\uff0c\u75c5\u5de3\u306b\u304a\u3044\u3066\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u5f62\u614b\u7570\u5e38\u3084\u30b0\u30ea\u30aa\u30fc\u30b7\u30b9\u4e0d\u5168\u304c\u8a8d\u3081\u3089\u308c\u308b\u3053\u3068\u304b\u3089\uff0c\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u6a5f\u80fd\u969c\u5bb3\u304c\u7591\u308f\u308c\u3066\u3044\u308b\uff0e\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u6d3b\u6027\u5316\u3084\u5897\u6b96\u3092\u4fc3\u9032\u3059\u308b\u4e3b\u8981\u306a\u5897\u6b96\u56e0\u5b50\u3068\u3057\u3066TGF-\u03b2\u304c\u77e5\u3089\u308c\u3066\u3044\u308b. TGF-\u03b2\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306f\uff0cSmad2/3\u306e\u30ea\u30f3\u9178\u5316\u3068\u6838\u5185\u79fb\u884c\u3092\u4ecb\u3057\u3066\u4f1d\u9054\u3055\u308c, Smurf2\u306b\u3088\u308a\u6291\u5236\u7684\u306b\u8abf\u7bc0\u3055\u308c\u3066\u3044\u308b\uff0e\u6211\u3005\u306f\u3053\u306e\u7d4c\u8def\u306e\u969c\u5bb3\u304c\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u6a5f\u80fd\u7570\u5e38\u3092\u62db\u304d\uff0c\u672c\u75be\u60a3\u306e\u75c5\u614b\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u63a8\u6e2c\u3057\u305f\uff0e\u672c\u7814\u7a76\u3067\u306f, LE\u3092\u4f34\u3044\u4e2d\u67a2\u795e\u7d4c\u75c7\u5019\u3092\u5448\u3057\u305f\u6210\u4eba\u767a\u75c7NIID\u306e\u5256\u691c\u4f8b5\u4f8b\u3068\u751f\u691c\u4f8b1\u4f8b\uff08With LE\u7fa4\uff09,\u304a\u3088\u3073\uff0c\u305d\u308c\u3089\u3092\u6709\u3055\u305a\u5256\u691c\u306b\u3066\u5076\u767a\u7684\u306bNI\u304c\u8a8d\u3081\u3089\u308c\u305f3\u4f8b\uff08Without LE\u7fa4\uff09\u306e\u5927\u8133\u7d44\u7e54\u3068, LE\u3092\u4f34\u3044\u4e2d\u67a2\u795e\u7d4c\u75c7\u5019\u3092\u5448\u3057\u76ae\u819a\u751f\u691c\u306b\u3066\u6210\u4eba\u767a\u75c7NIID\u3068\u8a3a\u65ad\u3055\u308c\u305f7\u4f8b\u306e\u76ae\u819a\u7d44\u7e54\u3092\u5bfe\u8c61\u3068\u3057\u3066, NI\u306e\u5f62\u614b\u5b66\u7684\u7279\u5fb4\u3068TGF-\u03b2\u30b7\u30b0\u30ca\u30eb\u95a2\u9023\u86cb\u767d\u306e\u767a\u73fe\u3092\u691c\u8a0e\u3057\u305f\uff0e\u305d\u306e\u7d50\u679c, NI\u306f\u6982\u306d90%\u304c\u30b0\u30ea\u30a2\u7d30\u80de\u306b\u51fa\u73fe\u3057\uff0c\u305d\u306e\u51fa\u73fe\u983b\u5ea6\u306fLE\u306e\u6709\u7121\u306b\u95a2\u9023\u3057\u306a\u304b\u3063\u305f\uff0e\u307e\u305f,With LE\u7fa4\u306eNI\u306f,Without LE\u7fa4\u3067\u306f\u898b\u3089\u308c\u306a\u3044\u5927\u304d\u306a\u30b5\u30a4\u30ba\u307e\u3067\u5e45\u5e83\u304f\u5206\u5e03\u3057\u3066\u3044\u305f\uff0e\u3055\u3089\u306b\uff0c\u30ea\u30f3\u9178\u5316Smad2/3\u306e\u6b63\u5e38\u306a\u6838\u5185\u306e\u767a\u73fe\u306f,LE\u306e\u6709\u7121\u306b\u95a2\u308f\u3089\u305a\uff0cNI\u3092\u6709\u3059\u308b\u7d30\u80de\u3067\u4f4e\u4e0b\u3084\u6d88\u5931\u3057\u3066\u3044\u305f\uff0e\u307e\u305f\uff0c\u4e00\u90e8\u306eNI\u306fSmurf2\u967d\u6027\u3092\u793a\u3057\uff0c\u305d\u306e\u967d\u6027\u7387\u306f\u76ae\u8cea\u7d30\u80de\u304a\u3088\u3073\u8133\u5ba4\u4e0a\u8863\u7d30\u80de\u306e\u3044\u305a\u308c\u306b\u304a\u3044\u3066\u3082With LE\u7fa4\u306b\u304a\u3044\u3066\u6709\u610f\u306b\u9ad8\u304f\uff0c\u76ae\u819a\u751f\u691c\u4f8b\u3067\u3082\u540c\u69d8\u3067\u3042\u3063\u305f\uff0e\u4ee5\u4e0a\u304b\u3089, NI\u5f62\u6210\u306f\u76f4\u63a5\u7684\u306b\u7d30\u80de\u969c\u5bb3\u306b\u306f\u7d50\u3073\u3064\u304b\u305a\uff0c\u75c5\u614b\u306e\u9032\u884c\u306b\u4f34\u3044\u305d\u306e\u69cb\u9020\u3084\u7d44\u6210\u304c\u5909\u5316\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u305f\uff0e\u307e\u305f, TGF-\u03b2\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u969c\u5bb3\u304c\u7d44\u7e54\u969c\u5bb3\u3092\u6765\u3059\u3088\u308a\u4ee5\u524d\u306e\u6bb5\u968e\u304b\u3089\u751f\u3058\uff0c\u4e00\u65b9\u3067, Smurf2\u306e\u904e\u5270\u767a\u73fe\u304c\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u6a5f\u80fd\u969c\u5bb3\u3084LE\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u305f\uff0e\u307e\u305f\uff0c\u76ae\u819a\u751f\u691c\u7d44\u7e54\u306b\u304a\u3051\u308bp62\u3068Smurf2\u306b\u5bfe\u3059\u308b\u6297\u4f53\u3092\u7528\u3044\u305f\u86cd\u5149\u514d\u75ab\u4e8c\u91cd\u67d3\u8272\u306b\u3088\u308bNI\u306e\u5171\u967d\u6027\u7387\u306e\u6e2c\u5b9a\u306f\u672c\u75be\u60a3\u306e\u8a3a\u65ad\u306e\u53c2\u8003\u3068\u306a\u308a\u5f97\u308b\uff0e", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "57190", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Sato, Tomoe"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u4f50\u85e4, \u670b\u6c5f"}], "nameIdentifiers": [{"nameIdentifier": "57189", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "132(3)_83-92.pdf", "filesize": [{"value": "6.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 6700000.0, "url": {"label": "132(3)_83-92.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/8123/files/132(3)_83-92.pdf"}, "version_id": "bcb20bac-00f9-499f-802b-72d94af24934"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "\u795e\u7d4c\u6838\u5185\u5c01\u5165\u4f53\u75c5", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u8a8d\u77e5\u75c7", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u767d\u8cea\u8133\u75c7", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u76ae\u819a\u751f\u691c", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TGF-\u03b2\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u6210\u4eba\u767a\u75c7\u795e\u7d4c\u6838\u5185\u5c01\u5165\u4f53\u75c5\u306e\u5c01\u5165\u4f53\u5f62\u6210\u306b\u304a\u3051\u308b\uff0cTGF-\u03b2\u30b7\u30b0\u30ca\u30eb\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u306e\u95a2\u4e0e\u306e\u691c\u8a0e", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u6210\u4eba\u767a\u75c7\u795e\u7d4c\u6838\u5185\u5c01\u5165\u4f53\u75c5\u306e\u5c01\u5165\u4f53\u5f62\u6210\u306b\u304a\u3051\u308b\uff0cTGF-\u03b2\u30b7\u30b0\u30ca\u30eb\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u306e\u95a2\u4e0e\u306e\u691c\u8a0e"}, {"subitem_title": "\u6210\u4eba\u767a\u75c7\u795e\u7d4c\u6838\u5185\u5c01\u5165\u4f53\u75c5\u306e\u5c01\u5165\u4f53\u5f62\u6210\u306b\u304a\u3051\u308b\uff0cTGF-\u03b2\u30b7\u30b0\u30ca\u30eb\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u306e\u95a2\u4e0e\u306e\u691c\u8a0e", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/878"], "permalink_uri": "http://hdl.handle.net/10191/50594", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2018-09-20"}, "publish_date": "2018-09-20", "publish_status": "0", "recid": "8123", "relation": {}, "relation_version_is_last": true, "title": ["\u6210\u4eba\u767a\u75c7\u795e\u7d4c\u6838\u5185\u5c01\u5165\u4f53\u75c5\u306e\u5c01\u5165\u4f53\u5f62\u6210\u306b\u304a\u3051\u308b\uff0cTGF-\u03b2\u30b7\u30b0\u30ca\u30eb\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u306e\u95a2\u4e0e\u306e\u691c\u8a0e"], "weko_shared_id": null}