@article{oai:niigata-u.repo.nii.ac.jp:00006694,
 author = {Koike, Kazuo and Matsuoka, Matsuzo},
 issue = {1},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {A 24-year-old woman with von Willebrand's disease who delivered a female infant vaginally without bleeding problems is described. Blood loss during delivery was 440 ml and within the normal range. Coagulation studies just before delivery revealed a striking improvement of factor VIII (VIII: C: 92% and VIIIR: AG: 200%), in contrast to those (VIII: C: 38% and VIIIR: AG: 22%) before pregnancy. However, abnormalities in coagulation studies of bleeding time (8 min), platelet retention rate (33.4%) and VIIIR: WF (30%) just before delivery remained unchanged, compared with those before pregnancy. The patient delivered a female infant with von Willebrand's disease vaginally without excess bleeding with the infusion of 500ml of fresh frozen plasma. The prophylactic use of factor VIII preparations during delivery of patients with von Willebrand's disease is discussed.},
 pages = {15--23},
 title = {Von Willebrand's disease in connection with the delivery of female infant without excess bleeding : A case report},
 volume = {34},
 year = {1986}
}