{"created":"2021-03-01T06:10:36.866744+00:00","id":6692,"links":{},"metadata":{"_buckets":{"deposit":"a4dc6aa0-8a13-4d38-96f5-ff42c2dcb730"},"_deposit":{"id":"6692","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6692"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006692","sets":["453:456","471:537:568:660"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1986-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Fundamental and clinical studies of ASPC, a new penicillin antibotic, were performed in the field of ophthalmology, and the results obtained were as follows. 1) The bacteriological activities of ASPC were similar to that of ABPC, CBPC and PIPC. The distribution of the sensitivity for 20 clinical isolates of S. aureus was in the range of 0.78～12.5μg/ml, with peaks at 0.78 μg/ml and 3.13 μg/ml, and the number of each of the strains was 5 (25%) respectively. The strains of P. aeruginosa were sensitive at 25 ～ > 100μg/ml and five of them were distributed under 50 μg/mｌ. 2) Ocular penetrations were examined in mature white rabbit eyes. After intravenous injection of 50 mg/kg, the aqueous level reached the peak of 6.0 μg/ml after 1/2 hours. Thereafter, it rapidly decreased and reached 0.7 μg/ml after 6 hours. Aqueous serum ratio at 30 minutes was 5.2%. The ocular tissue concentrations at 30 minutes after intravenous injection showed high levels in outer parts of the eye and relatively high levels in inner parts. 3) In the clinical study, the intravenous injection or drip infusion of 1.0 g or 2.0 g once or twice a day was performed in 12 cases, such as external hordeolum, acute dacryocystitis, corneal ulcer, corneal abscess, iridocyclitis purulenta and orbital infection. The results obtained were excellent in 3 cases, good in 8 cases and poor in 1 case. 4) No abnormal laboratory findings were recognized and no severe side effects were observed.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ooishi, Masao"}],"nameIdentifiers":[{"nameIdentifier":"53963","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakaue, Fujio"}],"nameIdentifiers":[{"nameIdentifier":"53964","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oomomo, Akiko"}],"nameIdentifiers":[{"nameIdentifier":"53965","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"34(1)_1-8.pdf","filesize":[{"value":"759.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"34(1)_1-8.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6692/files/34(1)_1-8.pdf"},"version_id":"310de785-71ed-4b13-80b4-401224400c0a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Fundamental and clinical studies for ophthalmic use of Aspoxicillin","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Fundamental and clinical studies for ophthalmic use of Aspoxicillin"},{"subitem_title":"Fundamental and clinical studies for ophthalmic use of Aspoxicillin","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","660"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-08"},"publish_date":"2015-10-08","publish_status":"0","recid":"6692","relation_version_is_last":true,"title":["Fundamental and clinical studies for ophthalmic use of Aspoxicillin"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:59.555465+00:00"}