@article{oai:niigata-u.repo.nii.ac.jp:00006678,
 author = {Inoue, Yoshiya},
 issue = {1},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {Twenty-eight cartilaginous tumors and normal bronchial cartilages were investigated immunohistochemically by using the antibodies to S-100 protein, alpha-1-antitrypsin (AT) and alpha-1-antichymotrypsin (ACT). All lesions and normal control specimens were revealed to have S-100 protein positive chondrocytes in various frequencies. The staining pattern of chondrocytes could be divided into three different types: D (diffusely stained) type, C (cytoplasmic dominant) type and N (nuclear dominant) type. All cartilaginous lesions except two immature teratomas had AT positive chondrocytes and these cells were found much more in malignant tumors than in benign ones. ACT positive chondrocytes were observed in two osteosarcomas, in all chondrosarcomas, and in one of two borderline cartilaginous tumors but no positive cells were seen in benign lesions. From these findings, the appearance of AT positive chondrocytes strongly indicates that the lesions were truely neoplastic. Furthermore the existence of ACT positive chondrocytes in tumors was considered to be a useful marker of malignancy.},
 pages = {35--44},
 title = {Immunohistochemical investigation of cartilaginous tumors},
 volume = {35},
 year = {1987}
}