@article{oai:niigata-u.repo.nii.ac.jp:00006677,
 author = {Suzuki, Toshimitsu},
 issue = {1},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {We examined ultrastructures of a pleomorphic liposarcoma originating from the epicardium with special reference to lipid droplets and nuclear inclusions in the sarcoma cells. Consequently, four types of lipid droplets were discriminated in tumor cells. The most frequent type was mainly round lipid droplets with moderate electron density and diamaters of 0.7 to 2.4 μm. The second most frequent type was round or elliptical lipid droplets with a halo or a central shaggy core of moderate electron density. Their size measured about 1.0 μm in diameter. Droplets of the third type were irregular and highly osmiophilic and resembled lysosomes, though they lacked a limiting membrane. The size of these droplets ranged from 0.6 to 2.0 μm in the largest diameter. Droplets of the fourth type were mainly round. Each had a large central vacuole and the diameter was from 0.6 to 2.0 μm. The last two types were much less frequent than the former two. These findings might indicate deviated lipogenesis of the sarcoma cells, compared with lipogenesis in normal fat cells. Several types of nuclear inclusion bodies were found mainly in the mononuclear tumor cells. They were fundamentally round and multi-lamellar bodies, with diameters of about 400 to 800nm. In addition, some nuclear bodies contained small lipid droplets, an aggregate of microfilaments or a round dense central core, and they occasionaly showed vacuolation suggestive of their degeneration. Fusion of several kinds of the nuclear bodies was also found and resulted in an irregular large inclusion. The origin of the nuclear bodies is obscure but they seem to indicate high nuclear activities of the sarcoma cells.},
 pages = {27--33},
 title = {Ultrastructure of lipid droplets and nuclear inclusions in a pleomorphic liposarcoma},
 volume = {35},
 year = {1987}
}