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The characterization of murine monoclonal antibodies against myelin-associated glycoprotein (MAG) of the human brain : II The difference of the antigenic determinant between clone, MC-P2, reacting with human natural killer cells and Leu-7
http://hdl.handle.net/10191/33575
http://hdl.handle.net/10191/33575adfa70c7-9378-42c9-8449-23e065b89fa0
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-10-07 | |||||
タイトル | ||||||
タイトル | The characterization of murine monoclonal antibodies against myelin-associated glycoprotein (MAG) of the human brain : II The difference of the antigenic determinant between clone, MC-P2, reacting with human natural killer cells and Leu-7 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The characterization of murine monoclonal antibodies against myelin-associated glycoprotein (MAG) of the human brain : II The difference of the antigenic determinant between clone, MC-P2, reacting with human natural killer cells and Leu-7 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myelin-associated glycoprotein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | measles virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | monoclonal antibody | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glycoprotein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | natural killer | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Tanaka, Masami
× Tanaka, Masami× Tanaka, Keiko× Nishizawa, Masatoyo× Inuzuka, Takashi× Baba, Hiroko× Sato, Shuzo× Miyatake, Tadashi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We examined the reactivity of five murine monoclonal antibodies against myelin-associated glycoprotein (MAG) with the measles virus. One of the three antibodies recognizing the carbohydrate moiety of MAG and human mononuclear cells (MC-P2) could react with the measles ELISA antigen but another two reacting with peptide moiety could not. Eleven murine monoclonal antibodies against human lymphocytes including anti-Leu-7, and anti-MAG monoclonal IgM from a patient with demyelinating polyneuropathy could not react with the measles ELISA antigen. However, in an immunoblotting study, two bands, 56 kDa and 63 kDa, were stained by MC-P2, which differed from those -H(78 kDa), P(69 kDa) and NP(60 kDa) - stained by the serum of a patient with subacute sclerosing panencephalitis. It may be possible that the antigens reacting with MC-P2 are derived from Vero cells used in a culture of measles virus. Anti-MAG monoclonal murine antibody (MC-P2) could NOT react with measles virus proteins. Although previously we have found in studying by inhibition assay, that MC-P2 bind directly to or close to the Leu-7 epitope, a chemical feature of the antigen of MC-P2 and Leu-7 seems to be different. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 35, 号 2, p. 53-61, 発行日 1987-09 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |