@article{oai:niigata-u.repo.nii.ac.jp:00006669, author = {Nemoto, Keiichi and Honma, Keiichi and Ohnishi, Yoshihisa and Kumano, Hidenori and Ohsaki, Naoki and Abe, Atsushi}, issue = {3-4}, journal = {Acta medica et biologica, Acta medica et biologica}, month = {Mar}, note = {Clinical, morphologic, cytochemical, immunologic, and ultrastructural features of a case of monocytic sarcoma which revealed pleural infiltration are described. The proliferating cells in the pleural cavity were not only large, bizarre cells, but also small-to medium-sized lymphoid cells. The large cells had the characteristics of monocyte showing a convoluted nucleus, abundant basophilic cytoplasm, numerous vacuoles, and irregular cytoplasmic projections. The cytochemical examination revealed that these cells had a diffuse, slightly-to-strongly positive reaction with α naphthyl butyrate esterase, acid phosphatase, β-glucuronidase, and aminopeptidase. The peroxidase reaction was completely negative and contained no cytoplasmic immunoglobulins. By surface phenotype, the cells showed positive reactions for Ia-like antigen, Mo 2 and My 4. Moreover, ultrastructurally the cells had phagolysosomes in the cytoplasm. On the other hand, the lymphoid cells expressed a phenotype of T cells (T 11 and Leu 3a positive). 4 months after the initial diagnosis, the patient died of heart failure and lung edema without leukemic manifestation. The present case was a peculiar type of monocytic proliferative disorder (monocytic sarcoma) limited to the pleura and pleural cavity.}, pages = {89--98}, title = {Monocytic sarcoma : A case report}, volume = {35}, year = {1988} }