@article{oai:niigata-u.repo.nii.ac.jp:00006665, author = {Sakuragawa, Nobuo and Kondo, Kaname and Niwa, Masahiro and Takahashi, Kaoru and Shimizu, Kimihiro}, issue = {1}, journal = {Acta medica et biologica, Acta medica et biologica}, month = {Jun}, note = {The stability studies of Factor VIII modified by PEG against serine proteases; thrombin, plasmin, and protein Ca, wrere carried out. PEG-Factor VIII was stable against plasmin and protein Ca, but was not stable against thrombin. These differences may be due to the different characteristics of each of the serine proteases. The PEG modification will be useful for therapeutic use by maintaining the level of Factor VIII much longer.}, pages = {1--5}, title = {Studies on the stability of factor VIII modified by polyethylene glycol}, volume = {36}, year = {1988} }