@article{oai:niigata-u.repo.nii.ac.jp:00006652, author = {Tsukioka, Kazuharu and Nakamata, Masami and Hirono, Shigeru}, issue = {1}, journal = {Acta medica et biologica, Acta medica et biologica}, month = {Jun}, note = {In order to elucidate the mechanism involved in Candida albicans (Candida)-induced asthma, the correlation between three different antibodies to Candida-the IgE antibody, precipitin and hemagglutinin- and the severity of Candida-induced asthma and the type of response after the bronchial provocation test (BPT) was analyzed. A diagnosis of Candida-induced asthma was made when the BPT was positive only for Candida. In the present study, 21 patients with Candida-induced asthma were investigated. Positive BPT responses consisted of immediate asthmatic responses (IAR), dual asthmatic responses (DAR) and late asthmatic responses (LAR), but only DAR and LAR were observed in the present study. The following results were obtained: 1) The titer of precipitin increased in accordance with the severity of asthma (p <0.01), but the titer of the IgE antibody and hemagglutinin did not show a consistent relation to the severity of asthma. 2) There was no significant correlation between the titer of the IgE antibody, precipitin and hemagglutinin to Candida and the type of response after BPT (DAR and LAR). These results indicate the possibility that there are cases in which precipitin may play an important role in the development of Candida-induced asthma, especially in sever cases.}, pages = {19--25}, title = {Correlation Between the Severity of Asthma Due to Candida Albicans and the Titer of Precipitin to Candida albicans}, volume = {37}, year = {1989} }