@article{oai:niigata-u.repo.nii.ac.jp:00006649,
 author = {Watanabe, Ken-ichi and Suzuki, Kaoru and Masani, Fumiaki and Hirokawa, Yoichi and Shibata, Akira and Maruyama, Shinji},
 issue = {2},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Sep},
 note = {The effect of a traditional Chinese medicine, Toki-shakuyaku-san (Dang-Gui-Shao-Yao-san), on placental blood flow was evaluated in spontaneously hypertensive rats (SHR). Pregnant SHR and Wistar-Kyoto rats (WKY) which were divided into 6 groups, were administered either water or 1.5% saline. The rats in the SHR+drug group and the SHR+saline+drug group were administered daily doses of 800mg/Kg of Toki-shakuyaku-san. No drug was administered to the WKY, SHR, WKY +saline and SHR+saline groups. Systolic blood pressure was measured on days 0, 5, 10, 15, 20 of pregnancy using the tail cuff method. The placental blood flow on the 20th day of pregnancy was determined using the electrolytic hydrogen clearance method. The placental blood flow (46±4 vs. 40±5/ml/min/100g, p<0.05) and fetal body weight (3.51±0.08 vs. 3.46 ±0.06g, p<0.05) in the SHR+saline+drug group were higher than those in the SHR+saline group, while there was no change in blood pressure. It is suggested that one of the etiologies of intrauterine growth retardation of the fetus is a decrease in the placental blood flow, and that Toki-shakuyaka-san accelerated development of the fetus by improving the placental blood flow.},
 pages = {91--95},
 title = {Effect of Toki-shakuyaku-san on the Fetal Development of Spontaneously Hypertensive Rats},
 volume = {37},
 year = {1989}
}