@article{oai:niigata-u.repo.nii.ac.jp:00006643, author = {Kobayashi, Eiji and Fujiwara, Michio}, issue = {3-4}, journal = {Acta medica et biologica, Acta medica et biologica}, month = {Dec}, note = {Mice are convenient for the elucidation of the mechanism of skin graft rejection because they are genetically well defined and economically available. Recently, the responsiveness of the T cell subset to the major histocompatibility complex (MHC) class I and II antigen has been analyzed and an immunohistochemical method has also been developed. For re-evaluation of the mechanism of skin graft rejection, we endeavored to develop more useful techniques of murine skin grafting. We implanted a couple of fullthickness skin pieces of 0.8 cm diameter to the graft beds prepared in the dorsal part of a recipient. Allogeneic coupled skin grafts were rejected at almost the same date and there was no difference in the survival days between the biopsied and non-biopsied groups. By the "coupled skin grafting" it became possible to observe one graft for skin rejection and analyze the other histologically and immunohistochemically.}, pages = {135--138}, title = {Coupled Skin Grafting for Use in the Studies of the Rejection Mechanism}, volume = {37}, year = {1989} }