{"created":"2021-03-01T06:10:33.248108+00:00","id":6637,"links":{},"metadata":{"_buckets":{"deposit":"fec8ec83-7fac-4ab6-a68e-16633ec32cd3"},"_deposit":{"id":"6637","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6637"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006637","sets":["453:456","471:537:568:647"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"44","bibliographicPageStart":"41","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Inhibitory activity of plasma on bacterial thermolysin was significantly higher in patients with idiopathic nephrotic syndrome (INS) at relapse than in those in remission, chance proteinuria and/or hematuria and control subjects. Simultaneously measured plasma concentrations of α2-macrogｌobulin (α2-M),  a large molecular proteinase inhibitor of human plasma, were also significantly elevated in INS. Sephadex G-200 gel-choromatography of the plasma revealed the thermolysin inhibitory activity was confined to the large molecular fractions. Sephacryl S-300 chromatography demonstrated  the coincidence of the thermolysin inhibitory actitivity with α2-M. The relation between the plasma thermolysin inhibitory actitivity and α2-M concentration showed a weak, but not significant, correlation (r=0.34, p<0.10), suggesting a possible alteration of the binding capacity (mol/mol) of increased plasma α2-M to proteinase in patients with INS. From these results it is suggested that the increased thermolysin inhibitory activity serves as a defense against invading pathogens by inactivating the proteinases elaborated by these organisms. This may be a compensatory reaction of the body for depressed cell immunity in INS.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Asami, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"53769","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishihara, Tohru"}],"nameIdentifiers":[{"nameIdentifier":"53770","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakano, Tokushi"}],"nameIdentifiers":[{"nameIdentifier":"53771","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakai, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"53772","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"38(1)_41-44.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"38(1)_41-44.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6637/files/38(1)_41-44.pdf"},"version_id":"97ec2064-0ba7-44f5-afa3-cd9958fd41ec"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Increased Proteinase Inhibitory Activity on Thermolysin in Idiopathic Nephrotic Syndrome","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Increased Proteinase Inhibitory Activity on Thermolysin in Idiopathic Nephrotic Syndrome"},{"subitem_title":"Increased Proteinase Inhibitory Activity on Thermolysin in Idiopathic Nephrotic Syndrome","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","647"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-01"},"publish_date":"2015-10-01","publish_status":"0","recid":"6637","relation_version_is_last":true,"title":["Increased Proteinase Inhibitory Activity on Thermolysin in Idiopathic Nephrotic Syndrome"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:56.670392+00:00"}