@article{oai:niigata-u.repo.nii.ac.jp:00006637,
 author = {Asami, Tadashi and Nishihara, Tohru and Nakano, Tokushi and Sakai, Kaoru},
 issue = {1},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Mar},
 note = {Inhibitory activity of plasma on bacterial thermolysin was significantly higher in patients with idiopathic nephrotic syndrome (INS) at relapse than in those in remission, chance proteinuria and/or hematuria and control subjects. Simultaneously measured plasma concentrations of α2-macrogｌobulin (α2-M),  a large molecular proteinase inhibitor of human plasma, were also significantly elevated in INS. Sephadex G-200 gel-choromatography of the plasma revealed the thermolysin inhibitory activity was confined to the large molecular fractions. Sephacryl S-300 chromatography demonstrated  the coincidence of the thermolysin inhibitory actitivity with α2-M. The relation between the plasma thermolysin inhibitory actitivity and α2-M concentration showed a weak, but not significant, correlation (r=0.34, p<0.10), suggesting a possible alteration of the binding capacity (mol/mol) of increased plasma α2-M to proteinase in patients with INS. From these results it is suggested that the increased thermolysin inhibitory activity serves as a defense against invading pathogens by inactivating the proteinases elaborated by these organisms. This may be a compensatory reaction of the body for depressed cell immunity in INS.},
 pages = {41--44},
 title = {Increased Proteinase Inhibitory Activity on Thermolysin in Idiopathic Nephrotic Syndrome},
 volume = {38},
 year = {1990}
}