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Increased Proteinase Inhibitory Activity on Thermolysin in Idiopathic Nephrotic Syndrome
http://hdl.handle.net/10191/33476
http://hdl.handle.net/10191/334766ea0576f-93df-4042-b92e-2b3231f15c46
名前 / ファイル | ライセンス | アクション |
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38(1)_41-44.pdf (1.1 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-10-01 | |||||
タイトル | ||||||
タイトル | Increased Proteinase Inhibitory Activity on Thermolysin in Idiopathic Nephrotic Syndrome | |||||
タイトル | ||||||
タイトル | Increased Proteinase Inhibitory Activity on Thermolysin in Idiopathic Nephrotic Syndrome | |||||
言語 | en | |||||
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言語 | eng | |||||
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資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Asami, Tadashi
× Asami, Tadashi× Nishihara, Tohru× Nakano, Tokushi× Sakai, Kaoru |
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内容記述タイプ | Abstract | |||||
内容記述 | Inhibitory activity of plasma on bacterial thermolysin was significantly higher in patients with idiopathic nephrotic syndrome (INS) at relapse than in those in remission, chance proteinuria and/or hematuria and control subjects. Simultaneously measured plasma concentrations of α2-macroglobulin (α2-M), a large molecular proteinase inhibitor of human plasma, were also significantly elevated in INS. Sephadex G-200 gel-choromatography of the plasma revealed the thermolysin inhibitory activity was confined to the large molecular fractions. Sephacryl S-300 chromatography demonstrated the coincidence of the thermolysin inhibitory actitivity with α2-M. The relation between the plasma thermolysin inhibitory actitivity and α2-M concentration showed a weak, but not significant, correlation (r=0.34, p<0.10), suggesting a possible alteration of the binding capacity (mol/mol) of increased plasma α2-M to proteinase in patients with INS. From these results it is suggested that the increased thermolysin inhibitory activity serves as a defense against invading pathogens by inactivating the proteinases elaborated by these organisms. This may be a compensatory reaction of the body for depressed cell immunity in INS. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 38, 号 1, p. 41-44, 発行日 1990-03 |
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出版者 | Niigata University School of Medicine | |||||
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収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
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値 | publisher |