{"_buckets": {"deposit": "fec8ec83-7fac-4ab6-a68e-16633ec32cd3"}, "_deposit": {"id": "6637", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6637"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006637"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1990-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "44", "bibliographicPageStart": "41", "bibliographicVolumeNumber": "38", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Inhibitory activity of plasma on bacterial thermolysin was significantly higher in patients with idiopathic nephrotic syndrome (INS) at relapse than in those in remission, chance proteinuria and/or hematuria and control subjects. Simultaneously measured plasma concentrations of \u03b12-macrog\uff4cobulin (\u03b12-M),  a large molecular proteinase inhibitor of human plasma, were also significantly elevated in INS. Sephadex G-200 gel-choromatography of the plasma revealed the thermolysin inhibitory activity was confined to the large molecular fractions. Sephacryl S-300 chromatography demonstrated  the coincidence of the thermolysin inhibitory actitivity with \u03b12-M. The relation between the plasma thermolysin inhibitory actitivity and \u03b12-M concentration showed a weak, but not significant, correlation (r=0.34, p\u003c0.10), suggesting a possible alteration of the binding capacity (mol/mol) of increased plasma \u03b12-M to proteinase in patients with INS. From these results it is suggested that the increased thermolysin inhibitory activity serves as a defense against invading pathogens by inactivating the proteinases elaborated by these organisms. This may be a compensatory reaction of the body for depressed cell immunity in INS.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Asami, Tadashi"}], "nameIdentifiers": [{"nameIdentifier": "53769", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishihara, Tohru"}], "nameIdentifiers": [{"nameIdentifier": "53770", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakano, Tokushi"}], "nameIdentifiers": [{"nameIdentifier": "53771", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakai, Kaoru"}], "nameIdentifiers": [{"nameIdentifier": "53772", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "38(1)_41-44.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "38(1)_41-44.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6637/files/38(1)_41-44.pdf"}, "version_id": "97ec2064-0ba7-44f5-afa3-cd9958fd41ec"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Increased Proteinase Inhibitory Activity on Thermolysin in Idiopathic Nephrotic Syndrome", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Increased Proteinase Inhibitory Activity on Thermolysin in Idiopathic Nephrotic Syndrome"}, {"subitem_title": "Increased Proteinase Inhibitory Activity on Thermolysin in Idiopathic Nephrotic Syndrome", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/647"], "permalink_uri": "http://hdl.handle.net/10191/33476", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-10-01"}, "publish_date": "2015-10-01", "publish_status": "0", "recid": "6637", "relation": {}, "relation_version_is_last": true, "title": ["Increased Proteinase Inhibitory Activity on Thermolysin in Idiopathic Nephrotic Syndrome"], "weko_shared_id": null}