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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.38 No.1

Increased Proteinase Inhibitory Activity on Thermolysin in Idiopathic Nephrotic Syndrome

http://hdl.handle.net/10191/33476
http://hdl.handle.net/10191/33476
6ea0576f-93df-4042-b92e-2b3231f15c46
名前 / ファイル ライセンス アクション
38(1)_41-44.pdf 38(1)_41-44.pdf (1.1 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-10-01
タイトル
タイトル Increased Proteinase Inhibitory Activity on Thermolysin in Idiopathic Nephrotic Syndrome
タイトル
言語 en
タイトル Increased Proteinase Inhibitory Activity on Thermolysin in Idiopathic Nephrotic Syndrome
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Asami, Tadashi

× Asami, Tadashi

WEKO 53769

Asami, Tadashi

Search repository
Nishihara, Tohru

× Nishihara, Tohru

WEKO 53770

Nishihara, Tohru

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Nakano, Tokushi

× Nakano, Tokushi

WEKO 53771

Nakano, Tokushi

Search repository
Sakai, Kaoru

× Sakai, Kaoru

WEKO 53772

Sakai, Kaoru

Search repository
抄録
内容記述タイプ Abstract
内容記述 Inhibitory activity of plasma on bacterial thermolysin was significantly higher in patients with idiopathic nephrotic syndrome (INS) at relapse than in those in remission, chance proteinuria and/or hematuria and control subjects. Simultaneously measured plasma concentrations of α2-macroglobulin (α2-M), a large molecular proteinase inhibitor of human plasma, were also significantly elevated in INS. Sephadex G-200 gel-choromatography of the plasma revealed the thermolysin inhibitory activity was confined to the large molecular fractions. Sephacryl S-300 chromatography demonstrated the coincidence of the thermolysin inhibitory actitivity with α2-M. The relation between the plasma thermolysin inhibitory actitivity and α2-M concentration showed a weak, but not significant, correlation (r=0.34, p<0.10), suggesting a possible alteration of the binding capacity (mol/mol) of increased plasma α2-M to proteinase in patients with INS. From these results it is suggested that the increased thermolysin inhibitory activity serves as a defense against invading pathogens by inactivating the proteinases elaborated by these organisms. This may be a compensatory reaction of the body for depressed cell immunity in INS.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 38, 号 1, p. 41-44, 発行日 1990-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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