{"created":"2021-03-01T06:10:33.183585+00:00","id":6636,"links":{},"metadata":{"_buckets":{"deposit":"38a8804a-e6ba-4182-a398-76aeee1a4499"},"_deposit":{"id":"6636","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6636"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006636","sets":["453:456","471:537:568:647"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"39","bibliographicPageStart":"37","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Histochemical and immunohistochemical analyses were carried out to determine the relationships of iron accumulation in hepatocellular carcinoma and hepatitis B virus antigens using 300 autopsy cases obtained from Nagasaki University Hospital. Iron accumulation in hepatocellular carcinoma was studied with Prussian blue reaction, and a positive reaction for hepatitis B core antigen and hepatitis B surface antigen were investigated by immunoperoxidase methods. Two cases of iron positive were observed in the cancerous tissue. These cases were hepatitis B core antigen-positive in the cancerous tissue, but hepatitis B surface antigen was negative in the same area. Therefore, hepatocellular carcinoma with hepatitis B surface antigen does not show iron accumulation, whereas the same tumor with hepatitis B core antigen is accompanied by iron accumulation. These findings suggest that hepatitis B core antigen produces the degeneration or collapse of the genes of hepatocellular carcinoma resulting in an iron metabolism disorder.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Senba, Masachika"}],"nameIdentifiers":[{"nameIdentifier":"53767","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawai, Kioko"}],"nameIdentifiers":[{"nameIdentifier":"53768","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"38(1)_37-39.pdf","filesize":[{"value":"697.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"38(1)_37-39.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6636/files/38(1)_37-39.pdf"},"version_id":"2375bdb4-b42e-4b46-ab52-0586381ccd36"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Iron Accumulation in Hepatocellular Carcinoma and the Role of Hepatitis B Core Antigen","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Iron Accumulation in Hepatocellular Carcinoma and the Role of Hepatitis B Core Antigen"},{"subitem_title":"Iron Accumulation in Hepatocellular Carcinoma and the Role of Hepatitis B Core Antigen","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","647"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-01"},"publish_date":"2015-10-01","publish_status":"0","recid":"6636","relation_version_is_last":true,"title":["Iron Accumulation in Hepatocellular Carcinoma and the Role of Hepatitis B Core Antigen"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:56.561742+00:00"}