@article{oai:niigata-u.repo.nii.ac.jp:00006636, author = {Senba, Masachika and Kawai, Kioko}, issue = {1}, journal = {Acta medica et biologica, Acta medica et biologica}, month = {Mar}, note = {Histochemical and immunohistochemical analyses were carried out to determine the relationships of iron accumulation in hepatocellular carcinoma and hepatitis B virus antigens using 300 autopsy cases obtained from Nagasaki University Hospital. Iron accumulation in hepatocellular carcinoma was studied with Prussian blue reaction, and a positive reaction for hepatitis B core antigen and hepatitis B surface antigen were investigated by immunoperoxidase methods. Two cases of iron positive were observed in the cancerous tissue. These cases were hepatitis B core antigen-positive in the cancerous tissue, but hepatitis B surface antigen was negative in the same area. Therefore, hepatocellular carcinoma with hepatitis B surface antigen does not show iron accumulation, whereas the same tumor with hepatitis B core antigen is accompanied by iron accumulation. These findings suggest that hepatitis B core antigen produces the degeneration or collapse of the genes of hepatocellular carcinoma resulting in an iron metabolism disorder.}, pages = {37--39}, title = {Iron Accumulation in Hepatocellular Carcinoma and the Role of Hepatitis B Core Antigen}, volume = {38}, year = {1990} }