{"created":"2021-03-01T06:10:32.800663+00:00","id":6630,"links":{},"metadata":{"_buckets":{"deposit":"892bf9e2-d948-40b9-b609-0a6fa4cb6a66"},"_deposit":{"id":"6630","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6630"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006630","sets":["453:456","471:537:568:646"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"95","bibliographicPageStart":"91","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To clarify the changes in plasma proteinase inhibitors in renal diseases, we measured the activity of plasma α_1-antichymotrypsin(α_1-Achy) under sueh conditions. The level of plasma α_1-Achy activity was found to be significantly lower in idiopathic nephrotic syndrome (INS) at relapse than in INS during remission, as well as in patients with chance proteinuria and/or hematuria (CPH) and in normal control subjects. The α_1-Achy activity in CPH was signiificantly elevated compared with that in INS (p<0.001) and normal controls (p<0.001). A significant inverse correlation was noted between the plasma α_1-Achy activity and the inhibitory effect of plasma on lymphocyte blastogenesis induced by Concanavalin A. Although the mechanism is unclear, the elevation of α_1-Achy in CPH (implicated in various types of glomerulonephritis) may be one of the responses of the body to counteract inflammatory processes by inactivating proteinase(s) released from infiltrating and/or proliferating cells in the glomeruli. The decreased plasma α_1-Achy level in INS may contribute to the depressed cellular immunity seen in INS.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Asami, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"53745","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishihara, Touru"}],"nameIdentifiers":[{"nameIdentifier":"53746","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakai, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"53747","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"38(2)_91-95.pdf","filesize":[{"value":"787.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"38(2)_91-95.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6630/files/38(2)_91-95.pdf"},"version_id":"660bb2dc-0d18-4166-b69a-9bb233eac9d8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Plasma α_1-antichymotrypsin Activity in Renal Diseases of Childhood","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Plasma α_1-antichymotrypsin Activity in Renal Diseases of Childhood"},{"subitem_title":"Plasma α_1-antichymotrypsin Activity in Renal Diseases of Childhood","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","646"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-01"},"publish_date":"2015-10-01","publish_status":"0","recid":"6630","relation_version_is_last":true,"title":["Plasma α_1-antichymotrypsin Activity in Renal Diseases of Childhood"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:57.093207+00:00"}