@article{oai:niigata-u.repo.nii.ac.jp:00006630,
 author = {Asami, Tadashi and Nishihara, Touru and Sakai, Kaoru},
 issue = {2},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {To clarify the changes in plasma proteinase inhibitors in renal diseases, we measured the activity of plasma α_1-antichymotrypsin(α_1-Achy) under sueh conditions. The level of plasma α_1-Achy activity was found to be significantly lower in idiopathic nephrotic syndrome (INS) at relapse than in INS during remission, as well as in patients with chance proteinuria and/or hematuria (CPH) and in normal control subjects. The α_1-Achy activity in CPH was signiificantly elevated compared with that in INS (p<0.001) and normal controls (p<0.001). A significant inverse correlation was noted between the plasma α_1-Achy activity and the inhibitory effect of plasma on lymphocyte blastogenesis induced by Concanavalin A. Although the mechanism is unclear, the elevation of α_1-Achy in CPH (implicated in various types of glomerulonephritis) may be one of the responses of the body to counteract inflammatory processes by inactivating proteinase(s) released from infiltrating and/or proliferating cells in the glomeruli. The decreased plasma α_1-Achy level in INS may contribute to the depressed cellular immunity seen in INS.},
 pages = {91--95},
 title = {Plasma α_1-antichymotrypsin Activity in Renal Diseases of Childhood},
 volume = {38},
 year = {1990}
}