@article{oai:niigata-u.repo.nii.ac.jp:00006601,
 author = {Maruyama, Soichi},
 issue = {2},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {In order to apply specific cytotoxic T lymphocytes (CTL) to human leukemia therapy, the induction of CTL against an allogeneic leukemia cell line from healthy volunteers and leukemia patients in remission was performed. Cytotoxicity was measured after mixed lymphocytetumor cell culture (MLTC) of peripheral blood lymphocytes (PBL) from healthy volunteers or patients and mitomycin C (MMC) treated YS-1 which is an alloleukemia cell line. The results were as follows: 1) CTL were induced from PBL of both healthy volunteers and leukemia patients in remission; 2) in leukemia patients, CTL activity varied according to disease conditions; 3) a secondary culture induced significantly higher CTL activity than a primary culture. These results suggest the feasibility of adoptive immunotherapy (AIT) for human leukemias using specific CTL.},
 pages = {83--90},
 title = {Induction of Cytotoxic T Lymphocytes against Allogeneic Leukemia Cell Line},
 volume = {39},
 year = {1991}
}