@article{oai:niigata-u.repo.nii.ac.jp:00006599,
 author = {Ooishi, Masao and Miyao, Masuya and Sakaue, Fujio and Tazawa, Hiroshi and Oomomo, Akiko},
 issue = {2},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {A 0.3% ophthalmic solution of norfloxacin (NFLX), one of the new quinolone compounds, was instilled into the rabbit eye 5 times every 5 min, and concentrations of NFLX in both cul-de-sac and the ocular tissues were measured. The following were noted: 1. NFLX concentrations exceeding the MIC90 against various bacteria were consistently demonstrated in the cul-de-sac up to 6 h after a single instillation in the normal eye. 2. On 5 instillations every 5 min, high NFLX concentrations were demonstrated in the outer parts of the normal eye. In the inflamed eye, the penetration of NFLX at high concentrations was noted in the outer and inner parts of the eye. 3. In the inflamed eye, the penetrating concentrations were higher than in the normal eye, especially in the aqueous humor, cornea, eyelid, and iris and ciliary body.},
 pages = {67--73},
 title = {Intraocular Penetration of Norfloxacin Eye Drops},
 volume = {39},
 year = {1991}
}