@article{oai:niigata-u.repo.nii.ac.jp:00006598,
 author = {Ohnishi, Yoshihisa and Emura, Iwao},
 issue = {2},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {The authors investigated hemopoietic stem cells in human embryonic and fetal liver. Pluripotent hemopoietic stem cells in the human embryonic liver were found to originate from the mesenchymal cells among the hepatocytes, and change their features with the development of the embryo. Ultrastructurally, these presumptive hemopoietic stem cells were classified into four subgroups (Types I-IV). Cells of Type I and Type II were large blastic cells resembling myeloblasts. Erythrocytic, megakaryocytic and granulocytic cell were derived from the presumptive hemopoietic stem Type II cells during the early stage of hepatic hemopoietis. On the other hand, Type IV cells were similar to small lymphocytes. Lymphocytes, together with the granulocytic, megakaryocytic and erythrocytic series, differentiated from the presumptive hemopoietic Type IV stem cells during the late stage of hepatic hemopoiesis. The presumptive hemopoietic Type IV stem cells migrated into the bone marrow. The relationship between immature hemopoietic cells and hemopoietic stromal cells seems to play an important role in the maturation of hemopoietic cells.},
 pages = {59--66},
 title = {Morphological Analysis of Human Blood Cell Differentiation, with Special Reference to Stem Cells},
 volume = {39},
 year = {1991}
}