@article{oai:niigata-u.repo.nii.ac.jp:00006590,
 author = {Kuwabara, Takeo and Ohno, Takao and Yuasa, Tatsuhiko and Miyatake, Tadashi},
 issue = {4},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Dec},
 note = {This paper describes the changes in proton (^1H) and sodium-23 (^<23>Na) magnetic resonance spectroscopy (MRS) occuring with the maturation and degeneration of skeletal muscle. Proton and ^<23>Na spin-lattice relaxation time (T_1) of the muscles of embryos and chicks were measured at 89.6 MHz and 23.7 MHz, respectively. As the tissue matured, the values of water proton T_I decreased along with water content. ^<23>Na-T_I shortened exponentially with maturation. Sodium content measured by ^<23>Na-MRS showed a similar decrease with maturation. The sodium content measured by flame photometry was always higher than that observed by ^<23>Na-MRS at any stage of maturation, and this magnetic resonance (MR) visibility decreased exponentially as the tissue matured. Proton T_1 of the hamster hindleg muscle with muscular dystrophy (DMP) was measured at 270 MHz using surface coil. The values lengthened until 11 weeks, and then shortened until 15 weeks. After that point, they remained unchanged. On the other hand, those of the controls shortened with age until 11 weeks, there reaching an "adult level" and remaining unchanged thereafter. Not only changes in water content accompanying skeletal muscle maturation, but also several factors such as functional development of cell membrane and structural macromolecule were suggested to have important effects on the relaxation times and MR visibility.},
 pages = {175--180},
 title = {Magnetic Resonance Spectroscopic Studies of the Maturation and Degeneration of Skeletal Muscle},
 volume = {39},
 year = {1991}
}