{"created":"2021-03-01T06:10:29.411129+00:00","id":6577,"links":{},"metadata":{"_buckets":{"deposit":"d384d99a-553f-473a-82a1-1dd43e1e1363"},"_deposit":{"id":"6577","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6577"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006577","sets":["453:456","471:537:568:638"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"52","bibliographicPageStart":"47","bibliographicVolumeNumber":"39(Supplement)","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Two kinds of monoclonal antibodies (mAbs) capable of inducing massive proteinuria in rats were produced in BALB/c mice with collagenase-treated Wistar rat glomeruli. The first mAb (mAb 5-1-6) reacts with the surface of glomerular epithelial cell foot processes, mainly to slit diaphragms. Protein excretion was initiated immediately following an injection of 2 mg mAb 5-1-6, and reached an average value of 138.5 mg/24 h on day 5. No histological abnormalities were noted except for partial retraction of epithelial foot processes at the peak of proteinuria. The minimum dose of mAb 5-1-6 required to induce proteinuria is 0.125 mg as injected dose. This dose corresponds to 12.8 μg as the amount of kidney binding antibody 1 h after injection, and 0.34 μg at 5 days. The second mAb (mAb 1-22-3) is capable of inducing not only proteinuria but also morphological changes in the mesangial region. mAb 1-22-3 binds in vitro to the limited mesangial cell surface facing endothelial cells. Reactivity of mAb 1-22-3 toward any other site in the kidney except the mesangial cell surface could not be detected. These mAbs may possibly serve as a means for clarifying the mechanism regulating the macromolecule permeability of glomerular capillary wall.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawachi, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"53544","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"39(Suppl.)_47-52.pdf","filesize":[{"value":"953.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39(Suppl.)_47-52.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6577/files/39(Suppl.)_47-52.pdf"},"version_id":"4f520fe6-93ee-4cf5-a99d-995582653549"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Proteinuria-Inducing Monoclonal Antibodies","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Proteinuria-Inducing Monoclonal Antibodies"},{"subitem_title":"Proteinuria-Inducing Monoclonal Antibodies","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","638"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-09-28"},"publish_date":"2015-09-28","publish_status":"0","recid":"6577","relation_version_is_last":true,"title":["Proteinuria-Inducing Monoclonal Antibodies"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:54.522530+00:00"}