{"_buckets": {"deposit": "d384d99a-553f-473a-82a1-1dd43e1e1363"}, "_deposit": {"id": "6577", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6577"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006577"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1991-03", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "52", "bibliographicPageStart": "47", "bibliographicVolumeNumber": "39(Supplement)", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Two kinds of monoclonal antibodies (mAbs) capable of inducing massive proteinuria in rats were produced in BALB/c mice with collagenase-treated Wistar rat glomeruli. The first mAb (mAb 5-1-6) reacts with the surface of glomerular epithelial cell foot processes, mainly to slit diaphragms. Protein excretion was initiated immediately following an injection of 2 mg mAb 5-1-6, and reached an average value of 138.5 mg/24 h on day 5. No histological abnormalities were noted except for partial retraction of epithelial foot processes at the peak of proteinuria. The minimum dose of mAb 5-1-6 required to induce proteinuria is 0.125 mg as injected dose. This dose corresponds to 12.8 \u03bcg as the amount of kidney binding antibody 1 h after injection, and 0.34 \u03bcg at 5 days. The second mAb (mAb 1-22-3) is capable of inducing not only proteinuria but also morphological changes in the mesangial region. mAb 1-22-3 binds in vitro to the limited mesangial cell surface facing endothelial cells. Reactivity of mAb 1-22-3 toward any other site in the kidney except the mesangial cell surface could not be detected. These mAbs may possibly serve as a means for clarifying the mechanism regulating the macromolecule permeability of glomerular capillary wall.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kawachi, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "53544", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "39(Suppl.)_47-52.pdf", "filesize": [{"value": "953.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 953300.0, "url": {"label": "39(Suppl.)_47-52.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6577/files/39(Suppl.)_47-52.pdf"}, "version_id": "4f520fe6-93ee-4cf5-a99d-995582653549"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Proteinuria-Inducing Monoclonal Antibodies", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Proteinuria-Inducing Monoclonal Antibodies"}, {"subitem_title": "Proteinuria-Inducing Monoclonal Antibodies", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/638"], "permalink_uri": "http://hdl.handle.net/10191/33459", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-09-28"}, "publish_date": "2015-09-28", "publish_status": "0", "recid": "6577", "relation": {}, "relation_version_is_last": true, "title": ["Proteinuria-Inducing Monoclonal Antibodies"], "weko_shared_id": null}