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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.39(Supplement)

Proteinuria-Inducing Monoclonal Antibodies

http://hdl.handle.net/10191/33459
http://hdl.handle.net/10191/33459
03330240-f952-4b26-a0b1-0664588d2487
名前 / ファイル ライセンス アクション
39(Suppl.)_47-52.pdf 39(Suppl.)_47-52.pdf (953.3 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-09-28
タイトル
タイトル Proteinuria-Inducing Monoclonal Antibodies
タイトル
言語 en
タイトル Proteinuria-Inducing Monoclonal Antibodies
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Kawachi, Hiroshi

× Kawachi, Hiroshi

WEKO 53544

Kawachi, Hiroshi

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抄録
内容記述タイプ Abstract
内容記述 Two kinds of monoclonal antibodies (mAbs) capable of inducing massive proteinuria in rats were produced in BALB/c mice with collagenase-treated Wistar rat glomeruli. The first mAb (mAb 5-1-6) reacts with the surface of glomerular epithelial cell foot processes, mainly to slit diaphragms. Protein excretion was initiated immediately following an injection of 2 mg mAb 5-1-6, and reached an average value of 138.5 mg/24 h on day 5. No histological abnormalities were noted except for partial retraction of epithelial foot processes at the peak of proteinuria. The minimum dose of mAb 5-1-6 required to induce proteinuria is 0.125 mg as injected dose. This dose corresponds to 12.8 μg as the amount of kidney binding antibody 1 h after injection, and 0.34 μg at 5 days. The second mAb (mAb 1-22-3) is capable of inducing not only proteinuria but also morphological changes in the mesangial region. mAb 1-22-3 binds in vitro to the limited mesangial cell surface facing endothelial cells. Reactivity of mAb 1-22-3 toward any other site in the kidney except the mesangial cell surface could not be detected. These mAbs may possibly serve as a means for clarifying the mechanism regulating the macromolecule permeability of glomerular capillary wall.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 39(Supplement), p. 47-52, 発行日 1991-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
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