@article{oai:niigata-u.repo.nii.ac.jp:00006565,
 author = {Ohtake, Masahiro and Koyama, Shuntaro and Sakaguchi, Takeo and Tsukada, Kazuhiro and Yoshida, Keisuke and Muto, Terukazu},
 issue = {2},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {The dose timing effect of FK-506 (FK) on liver regeneration was examined in 66% hepatectomized rats. FK at a dose of 0.1 mg/kg/day was given for three days starting on three different dates: 2 days before hepatectomy (FKI), 1 day before hepatectomy (FKII) and the day of hepatectomy (FKIII). Liver regeneration was evaluated by liver weight as a percentage of the body weight (LRR) and the mitotic index of the hepatocyte (MI) in the 3 days following hepatectomy. No significant change in LRR with an increase in MI was seen when FKI was given. Significant increases in both LRR and MI were obtained following FKII administration, but no change in LRR or MI was noted after FKIII administration. Food and water intake increased only when the rats received FKII. FKI and FKIII administration brought dysfunction of the liver, but no effect on the kidneys was induced by FK. The serum cholesterol concentration remained normal, but fatty tissue parameters were decreased in all animals with FK. These observations lead us to conclude that liver regeneration can be stimulated by FK with a reduction in the fatty tissue store, and FK has an optimal dose timing effect on regeneration without causing hepatotoxicity.},
 pages = {85--88},
 title = {Dose Timing Effect of FK-506 on Liver Regeneration in Partially Hepatectomized Rats},
 volume = {40},
 year = {1992}
}