@article{oai:niigata-u.repo.nii.ac.jp:00006564,
 author = {Aida, Sumihisa},
 issue = {2},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {Serum biliary ALP isoenzyme (ALP_1) was detected in 29.7% of rheumatoid arthritis (RA) patients studied, whereas it was undetectable in osteo-arthrosis patients. The positive activity of ALP_1 in the serum was accompanied by significant but mild increases in γ-GTP and LAP. These findings suggest that RA has an influence on the biliary tract. Furthermore, elevations of ALP_2 , ALP_3 , RAHA, CRP, ESR and IgA as well as a lowering of grip strength, stage and class in the ALP_1-positive RA patients were more marked than in the ALP_1-negative RA patients. These data suggest that the disease activity of RA is higher, and the bone resorption mechanism more enhanced in ALP_1-positive than in ALP_1-negative RA patients. There was no significant relationship between ALP_1 and AMA or ANA. This suggests that the possible overlapping of RA and PBC or SLE could be excluded from the reasons of the detection of ALP_1 activity.},
 pages = {79--83},
 title = {Relation between Rheumatoid Arthritis and Alkaline Phosphatase Isoenzymes},
 volume = {40},
 year = {1992}
}