@article{oai:niigata-u.repo.nii.ac.jp:00006555,
 author = {Iwanaga, Toshihiko and Han, Hongxia and Fujita, Tsuneo},
 issue = {3},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Sep},
 note = {The tips of villi in the monkey small intestine are demonstrated to contain a large, dense aggregation of macrophages in the lamina propria. They are intensely positive for acid phosphatase and, under the electron microscope, reveal numerous phagosomes whose contents resemble various portions of effete epithelial cells. The macrophages extend pseudopods to phagocytose apoptotic epithelial cells including goblet cells. Lymphocytes showing morphological features of LGLs (large granular lymphocytes) are dispersed in the epithelium of the villus tip. In the colon smaller macrophages with more inconspicuous phagosomes are seen loosely gathered beneath the superficial epithelium. Large macrophages, on the other hand, are aggregated around the cryptal base as well as between the lamina muscularis mucosae and an underlying lymphatic. The rectum, in turn, shows rather dense aggregations of macrophages beneath the superficial epithelium, forming intercryptal cell cords. This study suggests that in the monkey, as previously demonstrated in the guinea pig, effete epithelial cells are disposed of by macrophages, likely assisted by the cytotoxic activity of LGLs. The role of macrophages in the elimination of apoptotic epithelial cells is evident in the small intestine but less so in the large intestine.},
 pages = {105--113},
 title = {Macrophages Possibly Involved in the Disposal of Apoptotic Epithelial Cells in the Monkey Small and Large Intestine},
 volume = {40},
 year = {1992}
}