{"created":"2021-03-01T06:10:27.660599+00:00","id":6549,"links":{},"metadata":{"_buckets":{"deposit":"adbfda0c-15a5-4f96-a924-9a5bdbe76a65"},"_deposit":{"id":"6549","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6549"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006549","sets":["453:456","471:537:568:634"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"164","bibliographicPageStart":"157","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"After transferring spleen cells from C57BL/6 (B6) mice into C57BL/10Cr (B10Cr) mice, secondary responses to trinitrophenylated lipopolysaccharide in the recipient B10Cr mice were investigated. Though we observed a primary response to TNP-LPS in the recipient B10Cr mice to which spleen cells of B6 mice were transferred, cells primed with TNP-LPS caused stronger IgG responses than virgin cells. The production and maintenance of memory B cells were hardly affected in glioma bearing mice. However, the isotype-switch of IgM to IgG on a secondary response appeared weaker in\\nmemory B cells from mice bearing brain tumors than in those from normal B6 mice. In spite of the memory-cell transfer of B6 mice, glioma-bearing B10Cr mice could not maintain the immunological memory. The isotype-switch was also incomplete in these mice. The antigen-presenting ability of peritoneal exudate cells from glioma-bearing B6 mice was also weaker than that of normal B6 mice. Thus, we observed a disturbance of antibody responses to the thymus-independent antigens in glioma-bearing mice, which is attributed to the impaired antigen presenting ability of the macrophages.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshida, Seiichi"}],"nameIdentifiers":[{"nameIdentifier":"53441","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"53442","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"40(4)_157-164.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"40(4)_157-164.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6549/files/40(4)_157-164.pdf"},"version_id":"cd1be795-83aa-4501-ae0b-d70e438732a8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Secondary Antibody Responses to Thymus-independent Antigens in Mice with Brain Tumors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Secondary Antibody Responses to Thymus-independent Antigens in Mice with Brain Tumors"},{"subitem_title":"Secondary Antibody Responses to Thymus-independent Antigens in Mice with Brain Tumors","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","634"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-09-18"},"publish_date":"2015-09-18","publish_status":"0","recid":"6549","relation_version_is_last":true,"title":["Secondary Antibody Responses to Thymus-independent Antigens in Mice with Brain Tumors"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:52.663639+00:00"}