@article{oai:niigata-u.repo.nii.ac.jp:00006549, author = {Yoshida, Seiichi and Tanaka, Ryuichi}, issue = {4}, journal = {Acta medica et biologica, Acta medica et biologica}, month = {Dec}, note = {After transferring spleen cells from C57BL/6 (B6) mice into C57BL/10Cr (B10Cr) mice, secondary responses to trinitrophenylated lipopolysaccharide in the recipient B10Cr mice were investigated. Though we observed a primary response to TNP-LPS in the recipient B10Cr mice to which spleen cells of B6 mice were transferred, cells primed with TNP-LPS caused stronger IgG responses than virgin cells. The production and maintenance of memory B cells were hardly affected in glioma bearing mice. However, the isotype-switch of IgM to IgG on a secondary response appeared weaker in\nmemory B cells from mice bearing brain tumors than in those from normal B6 mice. In spite of the memory-cell transfer of B6 mice, glioma-bearing B10Cr mice could not maintain the immunological memory. The isotype-switch was also incomplete in these mice. The antigen-presenting ability of peritoneal exudate cells from glioma-bearing B6 mice was also weaker than that of normal B6 mice. Thus, we observed a disturbance of antibody responses to the thymus-independent antigens in glioma-bearing mice, which is attributed to the impaired antigen presenting ability of the macrophages.}, pages = {157--164}, title = {Secondary Antibody Responses to Thymus-independent Antigens in Mice with Brain Tumors}, volume = {40}, year = {1992} }