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Secondary Antibody Responses to Thymus-independent Antigens in Mice with Brain Tumors
http://hdl.handle.net/10191/33393
http://hdl.handle.net/10191/3339316050e2a-88c5-4cfe-ba41-fe32086ad12c
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-09-18 | |||||
タイトル | ||||||
タイトル | Secondary Antibody Responses to Thymus-independent Antigens in Mice with Brain Tumors | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Secondary Antibody Responses to Thymus-independent Antigens in Mice with Brain Tumors | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Yoshida, Seiichi
× Yoshida, Seiichi× Tanaka, Ryuichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | After transferring spleen cells from C57BL/6 (B6) mice into C57BL/10Cr (B10Cr) mice, secondary responses to trinitrophenylated lipopolysaccharide in the recipient B10Cr mice were investigated. Though we observed a primary response to TNP-LPS in the recipient B10Cr mice to which spleen cells of B6 mice were transferred, cells primed with TNP-LPS caused stronger IgG responses than virgin cells. The production and maintenance of memory B cells were hardly affected in glioma bearing mice. However, the isotype-switch of IgM to IgG on a secondary response appeared weaker in\nmemory B cells from mice bearing brain tumors than in those from normal B6 mice. In spite of the memory-cell transfer of B6 mice, glioma-bearing B10Cr mice could not maintain the immunological memory. The isotype-switch was also incomplete in these mice. The antigen-presenting ability of peritoneal exudate cells from glioma-bearing B6 mice was also weaker than that of normal B6 mice. Thus, we observed a disturbance of antibody responses to the thymus-independent antigens in glioma-bearing mice, which is attributed to the impaired antigen presenting ability of the macrophages. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 40, 号 4, p. 157-164, 発行日 1992-12 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |