@article{oai:niigata-u.repo.nii.ac.jp:00006547,
 author = {Nakatsuji, Tadako},
 issue = {4},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Dec},
 note = {Chronic immune reactions to syngeneic male (H-Y) antigen were studied in female and male Lewis rats. As donor rats, non-treated Lewis rats and pretreated Lewis rats were selected. Heterochromatic bodies stained with aceto-orcein were counted in the liver cells of these rats. The Barr body percentage of female liver cells ranged from 5.2±1.8% to 13.0±2.4%, while inactive Y (Y body) percentages of male liver cells ranged from 2.8±1.0% to 5.3±0.8%. Heterochromatic changes of liver cells increased to more than 9.0% in females immunized with non-treated male cells. The livers of the females, which were stimulated by male spleen cells, showed focal lymphocyte and eosinophil infiltrations into portal areas. Mild allograft rejection to H-Y antigen was characterized by the increased Barr body of hepatocytes. The injection of either male cells preimmunized with female cells or once pregnant female cells induced more aggressive chronic responses to H-Y antigen. Additionally added monoclonal antibodies (mAb), rat class I (anti-I-A) mAb and class II (anti-Ia) mAb reacted to accelerate the immune responses to H-Y antigen. The aggressive immune responses observed 260 days after immune induction were characterized by weight loss and reversible thymic dysplasia. The numbers of cortical nurse cells and medullary Hassall's bodies were decreased in the dysplastic thymuses. The cytoplasm of thymic tissue basophils was stained with both NaF-sensitive esterase and keratin.},
 pages = {145--150},
 title = {Increased Hepatic Barr Body and Thymic Epithelial Cell Dysplasia Found in Chronic Immune Responses to Rat Male (H-Y) Antigen},
 volume = {40},
 year = {1992}
}