@article{oai:niigata-u.repo.nii.ac.jp:00006546,
 author = {Kobayashi, Isao and Kurihara, Atsushi and Hamaoka, Satomi and Ozawa, Hideyuki and Yazaki, Akihiko and Tamura, Kohji and Amemiya, Norihiko and Endo, Takeshi and Mizoe, Asako and Kume, Shoji},
 issue = {4},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Dec},
 note = {Protein C and protein S activities were assayed in 508 healthy subjects and in 121 patients with cerebral thrombosis, and the frequencies of the congenital deficiencies of these physiological anticoagulant proteins were examined. In the healthy subjects, one case of heterozygous protein C deficiency (type I) and two cases of heterozygous protein S deficiency (type I and type II) were found. The frequencies of heterozygous protein C deficiency and heterozygous protein S deficiency in healthy subjects were 0.19% and 0.38%, respectively. In patients with cerebral thrombosis, one\ncase of heterozygous protein C deficiency (type I) and 8 cases of heterozygous protein S deficiency (type I, 3; type II, 3; type III, 2) were found. The frequencies of heterozygous protein C deficiency and heterozygous protein S deficiency in cerebral thrombosis were 0.8% and 6.4%, respectively. In cerebral thrombosis the frequency of heterozygous protein S deficiency was higher than that of heterozygous protein C deficiency; heterozygous protein S deficiency seems to be a risk factor for the later onset of cerebral thrombosis.},
 pages = {137--144},
 title = {The Frequency of Heterozygous Protein C Deficiency and Heterozygous Protein S Deficiency in Both Normal and Cerebral Thrombotic Conditions},
 volume = {40},
 year = {1992}
}