@article{oai:niigata-u.repo.nii.ac.jp:00006545, author = {Shigematsu, Hidekazu}, journal = {Acta medica et biologica, Acta medica et biologica}, month = {Mar}, note = {Reflux nephropathy is a part of renal disorders induced by intrarenal reflux. In intrarenal reflux of sterile urine, the extratublar efflux of Tamm-Horsfall protein initiates initially inflammation of foreign body type and later, sometimes, lymphomonocytic interstitial nephritis possibly under cellular immunity. In the reflux of infected urine, the initial purulent inflammation in tuburointerstitial tissue (acute pyelonephritis) could then change into Iymphomonocytic inflammation (chronic pyelonephritis) or sometimes granulomatous macrophagic inflammation (xanthogranulomatous pyelonephritis) also under cellular immunity. Thus reflux nephropathy could be recognized as rapidly progressive and destructive pyelonephritis induced by infected and/or sterile urine under vesicoureteral reflux.}, pages = {61--78}, title = {Intrarenal Reflex, Reflex Nephropathy, and Related Disorders}, volume = {40(Supplement)}, year = {1992} }