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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.41 No.1

Recent Advances in Basic and Clinical Studies of Glomerular Basement Membrane (GBM)

http://hdl.handle.net/10191/33311
http://hdl.handle.net/10191/33311
4cbb8cb8-4f17-47be-810a-e63e69defaf0
名前 / ファイル ライセンス アクション
41(1)_1-9.pdf 41(1)_1-9.pdf (2.3 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-09-11
タイトル
タイトル Recent Advances in Basic and Clinical Studies of Glomerular Basement Membrane (GBM)
タイトル
言語 en
タイトル Recent Advances in Basic and Clinical Studies of Glomerular Basement Membrane (GBM)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Nishi, Shinichi

× Nishi, Shinichi

WEKO 53376

Nishi, Shinichi

Search repository
Arakawa, Masaaki

× Arakawa, Masaaki

WEKO 53377

Arakawa, Masaaki

Search repository
抄録
内容記述タイプ Abstract
内容記述 Recent studies have revealed highly differentiated structures and functions of glomerular basement membrane (GBM). The most specific feature of the GBM is a three-layer structure, i.e. a lamina densa and two laminae rarae. The GBM consists of various components, such as type IV collagen, laminin and proteoglycans, in forming its three-dimensional network structure. This structure is thought to result from a self-assembling of each component and binding each other. The subclasses of the components have been differentiated and their distributions have been proved to be heterogeneous with the GBM. These structural characteristics are supposed to be related to the function of the GBM as a sieving membrane and as a base for cellular attachment. The mechanism of pathological damage to the structure and function of the GBM has been elucidated in various renal diseases with advances in the basic studies on the GBM. Matrix metalloprotainase (MMP) is considered to be important in GBM injuries of IgA nephropathy. Glycosylation of GBM components is suggested to be one of the causes of thickening of the GBM. A genetic mutation in α5(IV) chain of type IV collagen has been confirmed in Alport's syndrome.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 41, 号 1, p. 1-9, 発行日 1993-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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