@article{oai:niigata-u.repo.nii.ac.jp:00006530,
 author = {Aono, Takashi and Ohtake, Masahiro and Sakaguchi, Takeo and Sandoh, Norimasa and Tsukada, Kazuhiro and Hatakeyama, Katsuyoshi},
 issue = {2},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {Changes in portal venous flow (PVF) and portal venous pressure (PVP) were examined following sympathetic activation with cerebral ischemia in rats. Cerebral ischemia with carotid arterial occlusion (30 s) produced a reduction in PVF concomitant with an increase in PVP, and an inverse relationship between PVF and PVP was detected. Nanomolar quantities of adrenaline injected into the portal vein brought similar responses in PVF and PVP that were seen after cerebral ischemia. The PVF response produced by the ischemia disappeared when the hepatic splanchnic branch or bilateral splanchnic nerve was sectioned. At the same time, the PVP response produced by the ischemia was blocked by sectioning the bilateral splanchnic branches. In contrast, sectioning the hepatic splanchnic branch did not completely abolish the response. In the superior mesenteric vein, blood flow decreased with an increase in pressure after cerebral ischemia; these responses were blocked by sectioning the bilateral splanchnic nerves, but sectioning the hepatic splanchnic branch exerted no influence. Blood flow in the splenic vein was unaffected by the sympathetic activation. The results suggest that values of PVF and PVP following stimulation of splanchnic sympathetic nerve are determined by an increase in flow resistance due to the vasoconstriction of the adrenergic vasculature, and that the pressure in the superior mesenteric vein is tonically reflected in the PVP.},
 pages = {97--103},
 title = {Responses in Portal Venous Flow and Pressure Produced by Cerebral Sympathetic Activation in Rats},
 volume = {41},
 year = {1993}
}