@article{oai:niigata-u.repo.nii.ac.jp:00006523,
 author = {Ishii, Shiro},
 issue = {3},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Sep},
 note = {During the period between 1991 and 1993, an animal model for fetal asphyxia caused by umbilical cord compressions in utero was made using 12 pregnant goats of the Japanese Saanen strain. In fetal research, sheep have generally been used in making fetal preparation. In Japan, however, sheep are difficult to obtain as an experimental animal. In addition, the reproductive period of goats is longer than that of sheep. These factors led us to evaluate, goats as superior to sheep as an fetal experimental models. The gost fetuses were removed form the uterus at a gestational age of 110 to 130 days. After performing cannulation of the carotid arteries with placement of triolar cardioelectrodes and a balloon catheter around the umbilical cord, the fetuses were returned to the uterus to complete the gestational period. The time remaining until the termination of the postoperative pregnancy and available for various intrauterine monitoring procedures varied from 60 to 96 h. We observed fetal bradycardia by compressing the umbilical cord by inflating the cuff with saline. The fetal arterial pH value fell down from 7.38±0.07 to 7.12±0. 16. The continuation of the postoperative gestation for longer than 3 days indicated a return to the physiological state, as evidenced by the measured PO_2, PCO_2 and pH values. The results of this study show that we can deduce human fetal physiological events from the results of these experimental models using Japanese Saanen Goats. This animal experimental model using goats permits us study biochemical and biophysical measurements of the fetus in an aspyxiated condition in utero.},
 pages = {149--154},
 title = {A Method for Making an Animal Model for Fetal Asphyxia in the Goat},
 volume = {41},
 year = {1993}
}