@article{oai:niigata-u.repo.nii.ac.jp:00006518,
 author = {Soga, Kenji and Arai, Futoshi and Tsuruya, Takashi and Aikawa, Keiko and Toshima, Muneatsu and Shibasaki, Koichi and Aoyagi, Yutaka},
 issue = {4},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Dec},
 note = {In order to diagnose hepatocellular carcinoma (HCC), plasma levels of protein induced by vitamin K absence or antagonist-II (PIVKA-II) were determined by an enzyme-linked immunosorbent assay (ELISA). Positive reaction was noted in 34 (68%) of 50 patients with HCC, with PIVKA-II serving as an useful tumor marker in the estimation of HCC staging. On the other hand, the administration of vitamin K and the presence of jaundice were found to be important factors that affect plasma PIVKA-II levels. The administration of antibiotics with N-methylthiotetrazole at a dosage of 2 g/day for 3 days (total 6 g) did not seem to increase plasma concentrations of PIVKA-II levels. Thus, the measurement of the plasma PIVKA-II levels was useful for the diagnosis of HCC except for the disturbance of vitamin K utilization.},
 pages = {197--200},
 title = {Studies on Factors Affecting Plasma PIVKA-II Levels in Hepatocellular Carcinoma},
 volume = {41},
 year = {1993}
}