@article{oai:niigata-u.repo.nii.ac.jp:00006507, author = {Sato, Norimitsu L. and Kato, Akiko}, issue = {1}, journal = {Acta medica et biologica, Acta medica et biologica}, month = {Mar}, note = {1) subcutaneously inoculated Ehrlich Ascites Tumor (EAT) remained dormant in a ddY-drm mouse, while it grew and formed a solid tumor in a ddY-prg mouse. H-2 haplotype of ddY-drm was s and that of ddY-prg was q, which separated by two-way (EAT-dormant or EAT-progressive) selection over F+16 of a closed colony stock of ddY mice. Ly-1 and Ly-2 haplotypes, however, were not clearly distinct, showing a reduced expression of Ly-1.1 (11.0%), -1.2 (48.0%), Ly2.1 (32.0%) and -2.2 (32.0%) in the ddY-drm mouse while revealing a multi-expression of Ly-1.1 (70.4%), -1.2 (75.8%), Ly-2.1 (65.5%) and -2.2 (67.7%) in the ddY-prg mouse. 2) Adoptive immunotherapy against subcutaneous EAT outgrowth in the ddY-prg mouse was successfully undertaken beyond the difference of H-2 haplotype by transfer of ddY-drm spleen cells. Spleen cells from EAT-immunized ddY-drm mice were strongly effective. By combination with another mouse strain, such adoptive immunotherapy was unsuccessful except in a case of combination such as C57BL/6 (EAT-regressive) and C57BL/6-nu/nu (EAT-progressive). Some genetic background data were suggested for the success of the passive immune transfer of the murine tumor-dormant disposition.}, pages = {7--12}, title = {Passive Immune Transfer of Murine Tumor-dormant Disposition}, volume = {42}, year = {1994} }