@article{oai:niigata-u.repo.nii.ac.jp:00006504,
 author = {Sandoh, Norimasa},
 issue = {2},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {Tumorigenesis of the hepatic and biliary tract with N-nitroso-bis (2-oxopropyl) amine (BOP) was examined following the application of a high fat diet to hamsters. The animals were classified into four groups according to diet and BOP application: first, a standard diet; second, a high fat diet; third, BOP with a standard diet; fourth, BOP with a high fat diet. The high fat diet was rich in saturated fatty acids. No neoplasm was detected in any of the animals treated for 10 weeks, nor in the first and second groups of animals treated for 20 weeks. In the third group of animals, carcinogenic reaction appeared in the intra- and extra-hepatic bile ducts and in the gallbladder. In the fourth group of animals, carcinogenic reaction was induced in the intrahepatic and upper extrahepatic bile ducts. However, the incidence of carcinogenic reaction which developed in the lower extrahepatic bile duct and gallbladder was greater in the third group of animals than in the fourth group. These results suggest that a high fat diet containing large amounts of saturated fatty acids suppresses carcinogenesis in the lower extrahepatic bile tract.},
 pages = {71--78},
 title = {A High Fat Diet Containing Large Amounts of Saturated Fatty Acids Induced in Hamsters by Oral Administration of N-nitroso-bis (2-oxopropyl) Amine Suppresses Hepatic and Biliary Tract Carcinogenesis},
 volume = {42},
 year = {1994}
}