@article{oai:niigata-u.repo.nii.ac.jp:00006492, author = {Motoyama, Teiichi and Ogose, Akira and Hotta, Tetsuo and Inoue, Yoshiya and Matsubara, Toh and Watanabe, Hidenobu}, issue = {4}, journal = {Acta medica et biologica, Acta medica et biologica}, month = {Dec}, note = {This report describes an extremely rare case of extraskeletal mesenchymal chondrosarcoma. The tumor, occurring in the right leg of a male aged 35, was composed of undifferentiated mesenchymal cells and interspersed islands of well-differentiated cartilaginous tissue. Immunohistochemically, S-100 protein was detected in transitional forms between undifferentiated mesenchymal cells and well-differentiated cartilaginous cells as well as well-differentiated cartilaginous cells. Ultrastructurally, the undifferentiated mesenchymal cells had a narrow cytoplasm with a sparsity of organelles. The well-differentiated cartilaginous cells showed many features common to chondrocytes, such as abundant rough endoplasmic reticulum, multiple well-developed Golgi complexes, and microvillous and scalloped cytoplasmic membranes. The differentiation toward cartilaginous cells of undifferentiated mesenchymal cells was indicated by immunohistochemistry and electron microscopy.}, pages = {183--188}, title = {Extraskeletal Mesenchymal Chondrosarcoma : An Immunohistochemical and Ultrastructural Study}, volume = {42}, year = {1994} }