{"_buckets": {"deposit": "7f993476-3c29-424c-88f2-55a725788186"}, "_deposit": {"id": "6478", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6478"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006478", "sets": ["456", "624"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1995-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "16", "bibliographicPageStart": "11", "bibliographicVolumeNumber": "43", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "To determine the relationship between angiotensin II (Ang II) and glucose concentrations on cultured rat aortic vascular smooth muscle cells (VSMC), we examined 20 kinds of culture conditions for VSMC culture and measured [^3H] -DNA contents in all groups. Rat VSMC were obtained from the thoratic aorta of Wistar rats by the explant technique and cultured. Passages 3-5 were used for this experiment. VSMC were cultured for 7 days with four concentrations of additional glucose: 0 mM, 5.5 mM, 11 mM or 16.5 mM. The cells were then maintained in a serum-free medium and various amounts (0 M, 10^\u003c-9\u003eM, 10^\u003c-8\u003eM, 10^\u003c-7\u003eM or 10^\u003c-6\u003eM) of Ang II were replaced for 24 h. Afterward, 1μCi of [^3H]-thymidine was added to each well for 18h, and the radioactivities were counted. Compared to the group cultured without Ang II and glucose, the other 19 groups cultured with various amounts of glucose or Ang II were significantly higher in the levels of [^3H] -thymidine incorporation (TI). With Ang II from 10^\u003c-9\u003eM to 10^\u003c-7\u003eM, TI increased in a dose-dependent manner in each glucose concentration. In all Ang II concentrations used, the rates of TI on cultured VSMC in 11mM glucose were significantly higher than in other glucose concentrations. These results suggest that the concomitant increase in Ang II and glucose concentrations synergistically stimulates the proliferation of VSMC.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Igarashi, Masahiko"}], "nameIdentifiers": [{"nameIdentifier": "53120", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishiyama, Kiyoshi"}], "nameIdentifiers": [{"nameIdentifier": "53121", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Daimon, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "53122", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukase, Norio"}], "nameIdentifiers": [{"nameIdentifier": "53123", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morita, Yoshihiro"}], "nameIdentifiers": [{"nameIdentifier": "53124", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamatani, Keiichi"}], "nameIdentifiers": [{"nameIdentifier": "53125", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tominaga, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "53126", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasaki, Hideo"}], "nameIdentifiers": [{"nameIdentifier": "53127", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "43(1)_11-16.pdf", "filesize": [{"value": "989.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 989600.0, "url": {"label": "43(1)_11-16.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6478/files/43(1)_11-16.pdf"}, "version_id": "4a881807-18a0-4f9f-9d9c-758b06267b17"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The Effect of Angiotensin II on DNA Synthesis in Cultured Rat Aortic Vascular Smooth Muscle Cells with Various Glucose Concentrations", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The Effect of Angiotensin II on DNA Synthesis in Cultured Rat Aortic Vascular Smooth Muscle Cells with Various Glucose Concentrations"}, {"subitem_title": "The Effect of Angiotensin II on DNA Synthesis in Cultured Rat Aortic Vascular Smooth Muscle Cells with Various Glucose Concentrations", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "624"], "permalink_uri": "http://hdl.handle.net/10191/33192", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-08-31"}, "publish_date": "2015-08-31", "publish_status": "0", "recid": "6478", "relation": {}, "relation_version_is_last": true, "title": ["The Effect of Angiotensin II on DNA Synthesis in Cultured Rat Aortic Vascular Smooth Muscle Cells with Various Glucose Concentrations"], "weko_shared_id": null}