@article{oai:niigata-u.repo.nii.ac.jp:00006475, author = {Tsukimata, Jaime Koiti and Kodama, Makoto and Hirono, Satoru and Saeki, Makihiko and Kato, Kiminori and Hanawa, Haruo and Izumi, Tohru and Shibata, Akira and Suzuki, Kaoru and Kido, Shigeo and Kumakura, Makoto}, issue = {2}, journal = {Acta medica et biologica, Acta medica et biologica}, month = {Jun}, note = {The clinical course of the progression of myocarditis into dilated cardiomyopathy is not precisely understood. We observed two cases of acute-onset and persistent myocarditis in which the left ventricle developed into a dilated and poorly contracting state even after the healing of the myocarditis. Neither case had symptoms of previous infection. Similar characteristics of the two cases included a fulminant clinical course during the acute phase involving broad anterior myocardial damage, the persistence of myocardial inflammation over two months, and the resolution of myocardial inflammation by pulse therapy with methyl-prednisolone. The severity of myocardial damage during the acute phase and the persistence of myocarditis were considered responsible for the progression of myocarditis into post-myocarditis dilated cardiomyopathy. Pulse therapy using methyI-prednisolone appears useful in some patients with myocarditis which develops into dilated cardiomyopathy.}, pages = {109--115}, title = {Two Cases of Persistent Myocarditis Developing into Dilated Cardiomyopathy}, volume = {43}, year = {1995} }