@article{oai:niigata-u.repo.nii.ac.jp:00006474,
 author = {Sobaniec－LOTOWSKA, Maria E. and Nowak, Henryk Fr. and Sulkowski, Stanislaw},
 issue = {2},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {This work undertook an evaluation of ultrastructural examinations (by transmission electron microscopy (TEM) and samples for scanning electron microscopy (SEM)) of the endothelium and subendothelial space in the aorta of Wistar rats one, two and three months after ceasing an atherogenic diet rich in animal fat, cholesterol and methyl thiouracil. Changes corresponding to the early stage of the experimental atherosclerosis coexisting with formation of parietal platelet microthrombi were observed after three months of feeding the animals with the diet. No distinct signs of a regression of atherosclerotic changes were observed in the internal membrane one month after stopping the atherogenic diet. An increased adherence of blood white cells to impaired endothelium could be noticed. Two and three months after ceasing the applied diet, the atherosclerotic changes were still observed in 1/3 of the animals. However, in 2/3 of the animals, there was a distinct regression of the atherosclerotic changes connected with the reconstruction of small and shallow defects in the endothelial lining and a decrease in the thrombotic changes. Regenerated cells of the endothelium ("dark endothelial cells") included a relative increase in the number of some cellular organelle (mainly micropinocytotic vesicles, Weibel-Palade bodies) and numerous cytoplasmic processes. The subendothelial space below the regenerating endothelium was generally widened, and included a microfibrillar substance from which the basal membrane of the endothelial cells probably arose during the process of regeneration.},
 pages = {99--107},
 title = {Endothelial Changes in Rat Aorta after Terminating an Atherogenic Diet : A Scanning and Transmission Electron Microscopic Study},
 volume = {43},
 year = {1995}
}