@article{oai:niigata-u.repo.nii.ac.jp:00006473,
 author = {Aida, Sumihisa and Fujihara, Hideyoshi and Shimoji, Koki},
 issue = {2},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {The effect of ketamine on urine production was studied in 40 patients undergoing major surgery. Urine output both during and after ketamine-nitrous oxide anesthesia was significantly higher than that during (p<0.05) and after (p<0.01) halothane-nitrous oxide anesthesia. Urine output for one hour immediately after halothane-nitrous oxide anesthesia significantly (rS =0.462 (Spearman's rank correlation), p<0.05) correlated with the total infusion during the anesthesia, whereas that after ketamine-nitrous oxide anesthesia significantly (rS=0.525, p<0.05) correlated with the total dose of ketamine administered during the anesthesia. Moreover, a significant (p<0.05-0.01) increase in urine output was maintained for a few days after ketamine administration, this being dose-dependent. Urine osmolality after ketamine administration showed a significant inverse relationship (p<0.05) with the urine output. Furthermore, significant dose-dependent decreases in the serum levels of sodium (p<0.05-0.01) and chloride (p<0.05) were observed after ketamine administration. These results suggest that ketamine has a mild and long-lasting diuretic effect.},
 pages = {91--98},
 title = {Ketamine Anesthesia Increases Urine Output},
 volume = {43},
 year = {1995}
}