@article{oai:niigata-u.repo.nii.ac.jp:00006466, author = {Goto, Akira and Kodama, Shoji and Kase, Hiroaki and Saito, Mari and Tanaka, Kenichi and Ishii, Miwako}, issue = {3}, journal = {Acta medica et biologica, Acta medica et biologica}, month = {Sep}, note = {Assessment of the extent of glandular involvement by carcinoma in situ (CIS) of the uterine cervix is important when treatment by the laser conization is considered. A total of 67 subjects consisting of 28 cases of therapeutic conization (Group A), 16 cases of diagnostic conization plus simple hysterectomy (Group B), and 23 cases of simple hysterectomy (Group C) were reviewed histologically. Glandular involvement was observed 82.1% of all the patients, and 14.5% of them had no lesion in the surface squamous epithelium located upwards of the glandular involvement. Negative cases of the resected surgical margins of conization were found in 87.5% of Group A and 58.3% of Group B in surface squamous CIS, and 100% of Group A and 78.6% of Group B in lesions of glandular involvement. In the negative cases of the resected surgical margins of conization, average distances from the lesion in the surface squamous cell layer to the margins were 4532.7 μrn and 5394.1 μm in Groups A and B, respectively. On the other hand, average distances from glandular involvement to the margins were found to be shorter being 3465.1 μm and 4021.2 μm in Groups A and B, respectively. In six cases of positive margins in Group B, three cases had glandular involvement in the margins of conization and also in the removed uterus. In five cases with a residual lesion in the removed uterus, four had glandular involvement and two of those had the same lesions at the margins of conization. The results suggest that the conization for CIS should be performed under careful management in consideration of the possibility of residual glandular involvement, even if the squamous lesion of the surgical margins is negative.}, pages = {151--156}, title = {Glandular Involvement by Carcinoma in Situ of the Uterine Cervix}, volume = {43}, year = {1995} }