@article{oai:niigata-u.repo.nii.ac.jp:00006458,
 author = {Nakatsuji, Tadako},
 issue = {4},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Dec},
 note = {Postsplenectomy effects on neutrophil autoimmune reactions were studied in 27 splenectomized Lewis rats. Either levamisole or lysozyme was injected into the splenectomized and non-splenectomized Lewis rats. In five of the 27 splenectomized rats, CD^8+ T cell numbers of mesenteric lymph nodes (MLN) decreased to less than 10%. CD5^+ cell proliferation of MLN was found in several rats. Activated B cells reacted to anti CD5^+ antibody. Decreased phagocytosis of polymorphonuclear (PMN) neutrophils was shown in both rats immunized with either levamisole or lysozyme. Antilysozyme antibody titer was generally increased in all 16 rats treated with lysozyme. On the peripheral blood smear of one splenectomized female with high antilysozyme antibody, 81% PMN neutrophils had a hypersegmented hyperchromatic nucleus of more than 7 lobes. Most of the hypersegmented PMN neutrophils lost their peroxidase reactions. The hepatocytes of the male immunized with lysozyme after splenectomy showed mitochondrial proliferation and many peroxisomes. Well developed rough endoplasmic reticulums were also recognized at the perinuclear area. This study indicated that splenectomy intensified the auto PMN neutrophil reactions when degranulation of myeloperoxidase had been occurred by anti-lysozyme antibody. Lysozyme in the spleen worked to maintain the stability of mitochondrial protein synthesis in the liver.},
 pages = {223--228},
 title = {Effects of Splenectomy on Rat Polymorphonuclear Neutrophil Autoimmunity},
 volume = {43},
 year = {1995}
}