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Frequency of p53-positive Cells in Differing Histological Phases of Ulcerative Colitis
http://hdl.handle.net/10191/33217
http://hdl.handle.net/10191/33217becfd94f-0a74-4cad-a581-4d8a6f70e238
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
43(4)_197-203.pdf (772.2 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2015-08-31 | |||||
| タイトル | ||||||
| タイトル | Frequency of p53-positive Cells in Differing Histological Phases of Ulcerative Colitis | |||||
| タイトル | ||||||
| タイトル | Frequency of p53-positive Cells in Differing Histological Phases of Ulcerative Colitis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ulcerative colitis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | p53 expression | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | proliferative activity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | histological phase | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Matsuda, Keiji
× Matsuda, Keiji× Watanabe, Hidenobu× Jass, Jeremy R.× Ajioka, Yoichi× Kobayashi, Masaaki× Saito, Hideaki× Sasaki, Masataka× Yasuda, Kazuhiro× Kuwabara, Akifumi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Several reports attest to the absence of p53 immunoreactive cells within non-neoplastic colorectal mucosa, including histologically normal mucosa and inflamed mucosa from subjects with active ulcerative colitis (UC). Failure to detect p53 in these circumstances has been attributed to the short half-life of wild-type p53. Following our previous demonstration of p53 expression in non-neoplastic mucosa, we have studied specimens from ten subjects with ulcerative colitis with the aim of quantifying and correlating this aim with disease activity. The frequency of p53-positive tubules was 19.0% (245/1292) in active UC, 3.1% (46/1487) in resolving and 0.5% (4/863) in UC in remission and 0.3 % (59/17982) in controls. The number of p53-positive cells per tubule with p53-positive cells was 5.4±4.1 in active, 2.4±3.6 in resolving, and 1.3±0.5 in UC in remission and 1.1 ±0.3 in controls. Positive cells occurred singly and were limited to the proliferative zone of tubules in UC and controls. p53 labeling index (LI) in the proliferative zone was 9.0±7.7% in active, 1.5±1.4% in resolving, 1.1±0.5% in UC in remission and 1.2±0.3% in controls. Ki-67 LI in corresponding areas was 68.0± 16.4% in active, 63.1±10.2% in resolving, 48.5±14.4% in UC in remission and 60.9± 10.9% in controls. p53 LI/ Ki-67 LI percentage which is 100% or more in carcinomas with p53 protein overexpression was 14.3± 13.6% (max 52%) in active, 2.24±1.89% in resolving, 2.14±0.73% in UC in remission and 2.03±0.51% in controls. We conclude that p53 immunoreactive cells occur in non-neoplastic conditions and contain wild-type protein. Scattered expression of p53 is not a marker of neoplasia. If p53 immunostaining is to provide a useful diagnostic tool, then the limits of normal and abnormal expression need to be carefully defined. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 43, 号 4, p. 197-203, 発行日 1995-12 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
