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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.43 No.4

Frequency of p53-positive Cells in Differing Histological Phases of Ulcerative Colitis

http://hdl.handle.net/10191/33217
http://hdl.handle.net/10191/33217
becfd94f-0a74-4cad-a581-4d8a6f70e238
名前 / ファイル ライセンス アクション
43(4)_197-203.pdf 43(4)_197-203.pdf (772.2 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-08-31
タイトル
タイトル Frequency of p53-positive Cells in Differing Histological Phases of Ulcerative Colitis
タイトル
言語 en
タイトル Frequency of p53-positive Cells in Differing Histological Phases of Ulcerative Colitis
言語
言語 eng
キーワード
主題Scheme Other
主題 ulcerative colitis
キーワード
主題Scheme Other
主題 p53 expression
キーワード
主題Scheme Other
主題 proliferative activity
キーワード
主題Scheme Other
主題 histological phase
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Matsuda, Keiji

× Matsuda, Keiji

WEKO 53009

Matsuda, Keiji

Search repository
Watanabe, Hidenobu

× Watanabe, Hidenobu

WEKO 53010

Watanabe, Hidenobu

Search repository
Jass, Jeremy R.

× Jass, Jeremy R.

WEKO 53011

Jass, Jeremy R.

Search repository
Ajioka, Yoichi

× Ajioka, Yoichi

WEKO 53012

Ajioka, Yoichi

Search repository
Kobayashi, Masaaki

× Kobayashi, Masaaki

WEKO 53013

Kobayashi, Masaaki

Search repository
Saito, Hideaki

× Saito, Hideaki

WEKO 53014

Saito, Hideaki

Search repository
Sasaki, Masataka

× Sasaki, Masataka

WEKO 53015

Sasaki, Masataka

Search repository
Yasuda, Kazuhiro

× Yasuda, Kazuhiro

WEKO 53016

Yasuda, Kazuhiro

Search repository
Kuwabara, Akifumi

× Kuwabara, Akifumi

WEKO 53017

Kuwabara, Akifumi

Search repository
抄録
内容記述タイプ Abstract
内容記述 Several reports attest to the absence of p53 immunoreactive cells within non-neoplastic colorectal mucosa, including histologically normal mucosa and inflamed mucosa from subjects with active ulcerative colitis (UC). Failure to detect p53 in these circumstances has been attributed to the short half-life of wild-type p53. Following our previous demonstration of p53 expression in non-neoplastic mucosa, we have studied specimens from ten subjects with ulcerative colitis with the aim of quantifying and correlating this aim with disease activity. The frequency of p53-positive tubules was 19.0% (245/1292) in active UC, 3.1% (46/1487) in resolving and 0.5% (4/863) in UC in remission and 0.3 % (59/17982) in controls. The number of p53-positive cells per tubule with p53-positive cells was 5.4±4.1 in active, 2.4±3.6 in resolving, and 1.3±0.5 in UC in remission and 1.1 ±0.3 in controls. Positive cells occurred singly and were limited to the proliferative zone of tubules in UC and controls. p53 labeling index (LI) in the proliferative zone was 9.0±7.7% in active, 1.5±1.4% in resolving, 1.1±0.5% in UC in remission and 1.2±0.3% in controls. Ki-67 LI in corresponding areas was 68.0± 16.4% in active, 63.1±10.2% in resolving, 48.5±14.4% in UC in remission and 60.9± 10.9% in controls. p53 LI/ Ki-67 LI percentage which is 100% or more in carcinomas with p53 protein overexpression was 14.3± 13.6% (max 52%) in active, 2.24±1.89% in resolving, 2.14±0.73% in UC in remission and 2.03±0.51% in controls. We conclude that p53 immunoreactive cells occur in non-neoplastic conditions and contain wild-type protein. Scattered expression of p53 is not a marker of neoplasia. If p53 immunostaining is to provide a useful diagnostic tool, then the limits of normal and abnormal expression need to be carefully defined.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 43, 号 4, p. 197-203, 発行日 1995-12
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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