{"_buckets": {"deposit": "7d85a466-4bfa-43ac-bbd4-c1f4a82d36d3"}, "_deposit": {"id": "6454", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6454"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006454"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1995-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "203", "bibliographicPageStart": "197", "bibliographicVolumeNumber": "43", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Several reports attest to the absence of p53 immunoreactive cells within non-neoplastic colorectal mucosa, including histologically normal mucosa and inflamed mucosa from subjects with active ulcerative colitis (UC). Failure to detect p53 in these circumstances has been attributed to the short half-life of wild-type p53. Following our previous demonstration of p53 expression in non-neoplastic mucosa, we have studied specimens from ten subjects with ulcerative colitis with the aim of quantifying and correlating this aim with disease activity. The frequency of p53-positive tubules was 19.0% (245/1292) in active UC, 3.1% (46/1487) in resolving and 0.5% (4/863) in UC in remission and 0.3 % (59/17982) in controls. The number of p53-positive cells per tubule with p53-positive cells was 5.4\u00b14.1 in active, 2.4\u00b13.6 in resolving, and 1.3\u00b10.5 in UC in remission and 1.1 \u00b10.3 in controls. Positive cells occurred singly and were limited to the proliferative zone of tubules in UC and controls. p53 labeling index (LI) in the proliferative zone was 9.0\u00b17.7% in active, 1.5\u00b11.4% in resolving, 1.1\u00b10.5% in UC in remission and 1.2\u00b10.3% in controls. Ki-67 LI in corresponding areas was 68.0\u00b1 16.4% in active, 63.1\u00b110.2% in resolving, 48.5\u00b114.4% in UC in remission and 60.9\u00b1 10.9% in controls. p53 LI/ Ki-67 LI percentage which is 100% or more in carcinomas with p53 protein overexpression was 14.3\u00b1 13.6% (max 52%) in active, 2.24\u00b11.89% in resolving, 2.14\u00b10.73% in UC in remission and 2.03\u00b10.51% in controls. We conclude that p53 immunoreactive cells occur in non-neoplastic conditions and contain wild-type protein. Scattered expression of p53 is not a marker of neoplasia. If p53 immunostaining is to provide a useful diagnostic tool, then the limits of normal and abnormal expression need to be carefully defined.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Matsuda, Keiji"}], "nameIdentifiers": [{"nameIdentifier": "53009", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Hidenobu"}], "nameIdentifiers": [{"nameIdentifier": "53010", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Jass, Jeremy R."}], "nameIdentifiers": [{"nameIdentifier": "53011", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ajioka, Yoichi"}], "nameIdentifiers": [{"nameIdentifier": "53012", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobayashi, Masaaki"}], "nameIdentifiers": [{"nameIdentifier": "53013", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saito, Hideaki"}], "nameIdentifiers": [{"nameIdentifier": "53014", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasaki, Masataka"}], "nameIdentifiers": [{"nameIdentifier": "53015", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yasuda, Kazuhiro"}], "nameIdentifiers": [{"nameIdentifier": "53016", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuwabara, Akifumi"}], "nameIdentifiers": [{"nameIdentifier": "53017", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "43(4)_197-203.pdf", "filesize": [{"value": "772.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 772200.0, "url": {"label": "43(4)_197-203.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6454/files/43(4)_197-203.pdf"}, "version_id": "d9ccfe64-dfc4-48ce-b132-eb78eb76a32e"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "ulcerative colitis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "p53 expression", "subitem_subject_scheme": "Other"}, {"subitem_subject": "proliferative activity", "subitem_subject_scheme": "Other"}, {"subitem_subject": "histological phase", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Frequency of p53-positive Cells in Differing Histological Phases of Ulcerative Colitis", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Frequency of p53-positive Cells in Differing Histological Phases of Ulcerative Colitis"}, {"subitem_title": "Frequency of p53-positive Cells in Differing Histological Phases of Ulcerative Colitis", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/621"], "permalink_uri": "http://hdl.handle.net/10191/33217", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-08-31"}, "publish_date": "2015-08-31", "publish_status": "0", "recid": "6454", "relation": {}, "relation_version_is_last": true, "title": ["Frequency of p53-positive Cells in Differing Histological Phases of Ulcerative Colitis"], "weko_shared_id": null}